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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.2 No.2
- 발행연도
- 1997.6
- 수록면
- 121 - 128 (8page)
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This study was conducted to examine the atherogenic effect of high cholesterol diet(experimental diet) that influences changes of lipoprotein cholesterol metabolism and arterial wall. Seven NewZealand white rabbits were fed control diet, and the other 7 rabbits 2% cholesterol diet for 10 weeks. Results obtained from this study are as follows: 1) High cholesterol diet resulted in a gradual increase of plasma total cholesterol level, reaching up to 1422㎎/dl at the seventh week. 2) CETP(cholesteryl ester transfer protein) activity was significantly higher in high cholesterol group(64.9% at the 7th week) than control group(49.3% at the 7th week) during most of the experimental period except the 6th week. 3) The cholesterol supplementation induced fatty liver and a decrease of hepatic HMG-CoA reductase activities(2.1nmoles vs. 0.3nmoles) compared to control group. 4) Bands of apo B-l00 and apo E in plasma lipoprotein were thicker in high cholesterol-fed animals than control animals as visualized by SDS-PAGE. 5) Oxidizability of plasma lipoproteins measured in vitro was greater in high cholesterol group than control group, but vitamin E level higher in control group. 6) The effect of cholesterol feeding for 10 weeks also led to early fatty streaks in aortic intima. High choleserol feeding was atherogenic to rabbits, and this seems to be mediated through elevated CETP activities that regulate plasma HDL cholesterol level and decrease an efficiency of reverse cholesterol transport in lipoprotein cholesterol metabolism. The enhanced oxidizability of plasma lipoproteins and lowered vitamin E level may also contribute to the formation of fatty streaks in aorta of choleterol-fed rabbits.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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