지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The aim of the present study was to explore the neuroprotective effect and the possible mechanism of the PD-1 extracts on 1-methyl-4-phenyl-1,2,3,6-tetrahydrophridine (MPTP)-lesioned C57BL/6 mouse model of Parkinson’s disease (PD).
Methods: The mice were supplemented (or not) with 50 or 100 mg/kg/day of PD-1 for 2 weeks, after which MPTP was injected intraperitoneally. We observed that daily administration of PD-1 prevented MPTP-induced depletion of striatal DA, and maintained striatal and nigral tyrosine hydroxylase (TH) protein levels.
Results: Our results demonstrated that mice treated with PD-1 prior to MPTP administration showed more abundant TH-immunopositive (TH-ir) fibers and neurons than mice given only MPTP, indicating that PD-1 protects dopaminergic striatal fibers and nigral neurons from MPTP insults. Possible neuroprotective effect of PD-1 was further studied by the detection of antiapoptotic protein (bcl-2) and proapoptotic protein (Bax). In this assay, MPTP elevated the Bax protein and decreased the bcl-2 protein, while these expressions were prevented by PD-1 pre-treatment.
Conclusions: The present results suggest that PD-1 is able to protect dopaminergic neurons from MPTP-induced neuronal injury with anti-apoptotic activity being one of the possible mechanisms.
Methods: The mice were supplemented (or not) with 50 or 100 mg/kg/day of PD-1 for 2 weeks, after which MPTP was injected intraperitoneally. We observed that daily administration of PD-1 prevented MPTP-induced depletion of striatal DA, and maintained striatal and nigral tyrosine hydroxylase (TH) protein levels.
Results: Our results demonstrated that mice treated with PD-1 prior to MPTP administration showed more abundant TH-immunopositive (TH-ir) fibers and neurons than mice given only MPTP, indicating that PD-1 protects dopaminergic striatal fibers and nigral neurons from MPTP insults. Possible neuroprotective effect of PD-1 was further studied by the detection of antiapoptotic protein (bcl-2) and proapoptotic protein (Bax). In this assay, MPTP elevated the Bax protein and decreased the bcl-2 protein, while these expressions were prevented by PD-1 pre-treatment.
Conclusions: The present results suggest that PD-1 is able to protect dopaminergic neurons from MPTP-induced neuronal injury with anti-apoptotic activity being one of the possible mechanisms.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (35)
참고문헌 신청
1. [단행본] - 김은선 / 2006 / 뇌질환 치료제 (Ⅰ), 산업시장분석 / 한국과학기술 정보연구원 : 25 ~ 55
2. [단행본] - 서무규 / 1992 / 成人病 老人病學 / 고려의학 : 37 ~ 49
3. [학술지(정기간행물)] - Jenner P / 1998 / Understanding cell death in Parkinson’s disease / Ann Neurol 3 : S72 ~ S84
4. [학술지(정기간행물)] - Camins A / 2008 / Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches / Methods Find Exp Clin Pharmacol 30 (1) : 43 ~ 65
5. [학술지(정기간행물)] - Mancuso C / 2007 / Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders / Front Biosci 12 : 1107 ~ 1123
2. [단행본] - 서무규 / 1992 / 成人病 老人病學 / 고려의학 : 37 ~ 49
3. [학술지(정기간행물)] - Jenner P / 1998 / Understanding cell death in Parkinson’s disease / Ann Neurol 3 : S72 ~ S84
4. [학술지(정기간행물)] - Camins A / 2008 / Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches / Methods Find Exp Clin Pharmacol 30 (1) : 43 ~ 65
5. [학술지(정기간행물)] - Mancuso C / 2007 / Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders / Front Biosci 12 : 1107 ~ 1123
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Neuroprotective Effect of Benzylideneacetophenone Derivative on the MPTP Model of Neurodegeneration in Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)로 유도된 Parkinson's Disease 동물 모델을 이용한 향사양위탕의 신경 세포 보호 효과
JSCM : Journal of Sasang constitutional medicine
2014 .01
-
Rotenone- 및 MPTP-유도 파킨슨병 동물 모델에서 돌외 에탄올 추출물의 Dopamine 신경세포 보호작용
약학회지
2013 .01
-
Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson’s disease mouse model
Journal of Ginseng Research
2015 .04
-
Proteomic change by Korean Red Ginseng in the substantia nigra of a Parkinson’s disease mouse model
Journal of Ginseng Research
2018 .10
-
파킨슨병 동물 모델을 이용한 양릉천(GB34)의 선조체 내 도파민성신경세포 보호 기전 연구
Korean Journal of Acupuncture
2015 .01
-
간경보사(肝經補瀉)가 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine로 유도된 파킨슨병 동물 모델에 미치는 영향
Korean Journal of Acupuncture
2006 .01
-
Acupuncture at GB34 modulates laminin expression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced PD mouse model
Korean Journal of Acupuncture
2008 .01
-
MPTP로 유도된 Parkinson's disease 동물 모델에서 항염증효과를 통한 측백엽의 도파민신경보호 효과
대한본초학회지(본초분과학회지)
2014 .01
-
Neuroprotection of Dopaminergic Neurons by Hominis Placenta Herbal Acupuncture in in vitro and in vivo Models of Parkinson's Disease Induced by MPP+/MPTP Toxicity
대한침구의학회지
2015 .01
-
Delayed expression of c-fos mRNA in MPTP treated mouse
대한체질인류학회 학술대회 연제 초록
1996 .05
-
MPTP로 유도된 Parkinson's disease 동물 모델에서 열다한소탕 가감방 (MYH)의 신경 세포 보호 효과
JSCM : Journal of Sasang constitutional medicine
2015 .01
-
홍삼과 발효홍삼이 MPTP에 의해 유도된 생쥐의 신경독성에 미치는 영향
대한한의정보학회지
2013 .01
-
Peripheral Blood Immune Cell-based Biomarkers in Anti-PD-1/PD-L1 Therapy
Immune Network
2020 .02
-
풍요로운 환경(Environmental Enrichment)이 파킨슨병 동물 모델의 운동기능 향상에 미치는 효과
기초간호자연과학회지
2008 .01
-
Establishment of Parkinson’s Disease Model with MPTP in the Cynomolgus Monkey (Macaca fascicularis)
한국실험동물학회 학술발표대회 논문집
2013 .02
-
Overexpression of PD-L1 and PD-L2 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
Cancer Research and Treatment
2017 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Pathogenic Mediators of Amyloid Neurotoxicity in Alzheimer`s Disease
Kam TI
,
Song S
,
Gwon Y
외 3명
한국실험동물학회 학술발표대회 논문집
2015
.08
Mercury induced the Accumulation of Amyloid Beta (Aβ) in PC12 Cells : The Role of Production and Degradation of Aβ
Ji-Won Song
,
Byung-Sun Choi
Toxicological Research
2013
.12
아밀로이드 베타에 의한 신경세포 사멸과 이에 대한 열충격 단백질 90의 세포 보호효과
이현정
,
김도희
,
김옥현
외 4명
해부·생물인류학
2008
.03
6-OHDA로 유도된 파킨슨 증후군의 동물 모델에서 도파민성 신경세포의 손실과 미세아교세포 활성 사이의 관계
이진숙
,
이지용
,
조원길
외 2명
해부·생물인류학
2013
.03
A Survey of Movement Symptom and Quantification Method in Parkinson’s Disease
권다은
,
김요섭
,
김상준
외 2명
Journal of KIISE
2019
.04
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-519-000262185