Single Oral Dose Toxicity Test of Blue Honeysuckle Concentrate in Mice

Hyung-Soo Kim; Sang-In Park; Seung-Hoon Choi; Chang-Hyun Song; Soo-Jin Park; Yong-Kook Shin; Chang-Hyun Han; Young Joon Lee; Sae-Kwang Ku

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자료유형: 학술저널

저자정보: Hyung-Soo Kim (Daegu Haany University) Sang-In Park (Daegu Haany University) Seung-Hoon Choi (Daegu Haany University) Chang-Hyun Song (Daegu Haany University) Soo-Jin Park (Daegu Haany University) Yong-Kook Shin (Semyung University) Chang-Hyun Han (Korea Institute of Oriental Medicine) Young Joon Lee (Daegu Haany University) Sae-Kwang Ku (Daegu Haany University)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.31 No.1

발행연도: 2015.3

수록면: 61 - 68 (8page)

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The objective of this study was to obtain single oral dose toxicity information for concentrated and lyophilized powder of blue honeysuckle (Lonicera caerulea L., Caprifoliaceae; BHcL) in female and male ICR mice to aid in the process of developing natural origin medicinal ingredients or foods following proximate analysis and phytochemical profile measurement. The proximate analysis revealed that BHcL had an energy value of 3.80 ㎉/g and contained 0.93 g/g of carbohydrate, 0.41 g/g of sugar, 0.02 g/g of protein, and 0.20 ㎎/g of sodium. BHcL did not contain lipids, including saturated lipids, trans fats, or cholesterols. Further, BHcL contained 4.54% of betaine, 210.63 ㎎/g of total phenols, 159.30 ㎎/g of total flavonoids, and 133.57 ㎎/g of total anthocyanins. Following administration of a single oral BHcL treatment, there were no treatment-related mortalities, changes in body weight (bw) or organ weight, clinical signs, necropsy or histopathological findings up to 2,000 ㎎/㎏ bw, the limited dosage for rodents of both sexes. We concluded that BHcL is a practically non-toxic material in toxicity potency.

#Single oral dose toxicity #Mouse #Blue honeysuckle #Proximate analysis #Phytochemical analysis

참고문헌 (30)

참고문헌 신청

Saravanan, N. / 2007 / Antioxidant effect of 2-hydroxy-4-methoxy benzoic acid on ethanol induced hepatotoxicity in rats / J. Pharm. Pharmacol. 59:445~453

Noh, J. R. / 2011 / Hepatoprotective effect of Platycodon grandiflorum against chronic ethanol-induced oxidative stress in C57BL/6 mice / Ann. Nutr. Metab. 58:224~231

이지은 / 2003 / 반하의 4주 반복투여독성 평가 / Laboratory Animal Research 19(3):127~141

Choi, J. S. / 2014 / Single-dose oral toxicity of fermented rice extracts (FREs): a 14-day observation / Pak. J. Pharm. Sci. 27:129~137

구세광 / 2013 / Single Oral Dose Toxicity Study of Prebrewed Armeniacae Semen in Rats / 한국독성학회지 29(2):91~98

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