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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.20 No.1
- 발행연도
- 2015.3
- 수록면
- 52 - 59 (8page)
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This study was to investigate the preventive effect of taemyeongcheong (TMC, a Korean traditional health drink) on acetaminophen (APAP, 800 mg/kg BW)-induced hepatic damage in ICR mice. TMC is prepared from Saururus chinensis, Taraxacum officinale, Zingiber officinale, Cirsium setidens, Salicornia herbacea, and Glycyrrhizae. A high dose of TMC (500 mg/kg BW) was found to decrease APAP-induced increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase. TMC pretreatment also increased the hepatic levels of hepatic catalase, superoxide dismutase, glutathione peroxidase, and glutathione, and reduced serum levels of the inflammatory cytokines tumor necrosis factor (TNF)-? and interleukin (IL)-6 in mice administered APAP (P＜0.05). TMC (500 mg/kg BW) reduced hepatic mRNA levels of TNF-?, IL-1?, IL-6, COX-2, and iNOS by 87%, 84%, 89%, 85%, and 88%, respectively, in mice treated with APAP (P＜0.05). Furthermore, histological observations suggested TMC pretreatment dose-dependently prevented APAP-induced hepatocyte damage. These results suggest that TMC could be used as a functional health drink to prevent hepatic damage.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Mitchell JR / 1973 / Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism / J Pharmacol Exp Ther 187 : 185 ~ 194
2. [학술지(정기간행물)] - Dahlin DC / 1984 / N-acetyl-p-benzoquinone imine : a cytochrome P-450-mediated oxidation product of acetaminophen / Proc Natl Acad Sci USA 81 : 1327 ~ 1331
3. [학술지(정기간행물)] - Nelson SD / 1990 / Molecular mechanisms of the hepatotoxicity caused by acetaminophen / Semin Liver Dis 10 : 267 ~ 278
4. [학술지(정기간행물)] - Lores Arnaiz S / 1995 / Oxidative stress by acute acetaminophen administration in mouse liver / Free Radic Biol Med 19 : 303 ~ 310
5. [보고서] - Fujiwara K / 1987 / Treatment trial of traditional oriental medicine in chronic viral hepatitis. In New Trends in Peptic Ulcer and Chronic Hepatitis: Chronic Hepatitis : 141 ~ 146
2. [학술지(정기간행물)] - Dahlin DC / 1984 / N-acetyl-p-benzoquinone imine : a cytochrome P-450-mediated oxidation product of acetaminophen / Proc Natl Acad Sci USA 81 : 1327 ~ 1331
3. [학술지(정기간행물)] - Nelson SD / 1990 / Molecular mechanisms of the hepatotoxicity caused by acetaminophen / Semin Liver Dis 10 : 267 ~ 278
4. [학술지(정기간행물)] - Lores Arnaiz S / 1995 / Oxidative stress by acute acetaminophen administration in mouse liver / Free Radic Biol Med 19 : 303 ~ 310
5. [보고서] - Fujiwara K / 1987 / Treatment trial of traditional oriental medicine in chronic viral hepatitis. In New Trends in Peptic Ulcer and Chronic Hepatitis: Chronic Hepatitis : 141 ~ 146
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UCI(KEPA) : I410-ECN-0101-2016-594-001353435