지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 115 - 121 (7page)
이용수
초록· 키워드
오류제보하기
Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Pulsatilla koreana (P. koreana) is a perennial plant that grows around Korea and it has various pharmacological effects such as anti-cancer and anti-inflammatory activity. However, the regulatory effects of P. koreana in intestinal inflammation are not yet understood. This study attempted to determine the effect of P. koreana in dextran sulfate sodium (DSS)-induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of P. koreana attenuated DSS-induced the weight loss, colon shortening and Disease activity index in mice. Additionally, P. koreana inhibited the cyclooxygenase-2 and prostaglandin E2 levels in DSS-treated colon tissues. These results provide experimental evidence that P. koreana might be a useful therapeutic medicine for patients with UC.
목차
INTRODUCTION
MATERIALS AND METHODS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)] - Agoff SN / 2000 / The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia / Am J Pathol 157 : 737 ~ 745
[학술지(정기간행물)] - Bouma G / 2003 / The immunological and genetic basis of inflammatory bowel disease / Nat Rev Immunol 3 : 521 ~ 533
[학술지(정기간행물)] - Brune K / 2004 / Selective cyclooxygenase-2 inhibitors: similarities and differences / Scand J Rheumatol 33 : 1 ~ 6
[학술지(정기간행물)] - Camuesco D / 2005 / Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3)polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis / J Nutr 135 : 687 ~ 694
[학술지(정기간행물)] - To Dao Cuong / 2009 / Cytotoxic Compounds from the Roots of Pulsatilla koreana / Natural Product Sciences 15 (4) : 250 ~ 255
[학술지(정기간행물)] - Bouma G / 2003 / The immunological and genetic basis of inflammatory bowel disease / Nat Rev Immunol 3 : 521 ~ 533
[학술지(정기간행물)] - Brune K / 2004 / Selective cyclooxygenase-2 inhibitors: similarities and differences / Scand J Rheumatol 33 : 1 ~ 6
[학술지(정기간행물)] - Camuesco D / 2005 / Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3)polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis / J Nutr 135 : 687 ~ 694
[학술지(정기간행물)] - To Dao Cuong / 2009 / Cytotoxic Compounds from the Roots of Pulsatilla koreana / Natural Product Sciences 15 (4) : 250 ~ 255
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Flavonoid Glycosides from the Flowers of Pulsatilla koreana Nakai
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Effect of functional foods containing lactic acid bacteria on DSS-induced colitis
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American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice
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Unripe apple alleviates dextran sodium sulfate(DSS)-induced ulcerative colitis in BALB/c mice
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The anti-oxidative and anti-inflammatory effect of Psoralea corylifolia on Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice
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Preventive Effects of Spirogyra neglecta and a Polysaccharide Extract against Dextran Sodium Sulfate Induced Colitis in Mice
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해동피를 포함한 한약제제 HPL-01의 Dextran sodium sulfate 유도 궤양성 대장염 완화 효과
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Gossypetin supressed DSS-induced colitis through p38 signaling pathway
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Falcarindiol from Angelica koreana Down-regulated IL-8 and Up-regulated IL-10 in Colon Epithelial Cells
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UCI(KEPA) : I410-ECN-0101-2016-510-001658768