지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 52 - 57 (6page)
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초록· 키워드
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Mutant p53 (R280K) is highly expressed in MDAMB-231 triple-negative human breast cancer cells. Currently, we reported the role of mutant p53-R280K in mediating the survival of MDA-MB-231 cells in vitro. The present study was undertaken to determine whether mutant p53-R280K affects breast cancer cell growth in vivo. To this end, we used small interfering RNA to knockdown the level of mutant p53- R280K in MDA-MB-231 cells. Silencing of mutant p53- R280K in MDA-MB-231 cells causes substantial tumor regression of established xenografts in vivo. In xenograft model for breast cancer, silencing of mutant p53-R280K in MDAMB-231 cells significantly inhibited the tumor growth. Moreover, TUNEL assay showed more occurrence of apoptotic cells in mutant p53-R280K silenced tumors compared to control. Our data indicate that mutant p53-R280K has an important role in mediating tumor growth of MDA-MB-231 cells in vivo. Taken together, this study suggests that endogenous mutant p53-R280K could be used as a therapeutic target for breast cancer cells harboring this TP53 missense mutation.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHOD
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (12)
참고문헌 신청
Selivanova, G. (2004) P53: Fighting Cancer. Curr. Cancer. Drug Targets 4: 385-402.
Horn, H. F. and K. H. Vousden (2007) Coping with stress: multiple ways to activate p53. Oncogene. 26: 1306-1316.
Molchadsky, A., N. Rivlin, R. Brosh, V. Rotter, and R. Sarig (2010) P53 is balancing development, differentiation and de-differentiation to assure cancer prevention. Carcinogenesis. 31: 1501-1508.
Brosh, R. and V. Rotter (2009) When mutants gain new powers: news from the mutant p53 field. Nat. Rev. Cancer. 9: 701-713.
Walerych, D., M. Napoli, L. Collavin, and G. Del-Sal (2012) The rebel angel: mutant p53 as the driving oncogene in breast cancer. Carcinogenesis. 33: 2007-2017.
Horn, H. F. and K. H. Vousden (2007) Coping with stress: multiple ways to activate p53. Oncogene. 26: 1306-1316.
Molchadsky, A., N. Rivlin, R. Brosh, V. Rotter, and R. Sarig (2010) P53 is balancing development, differentiation and de-differentiation to assure cancer prevention. Carcinogenesis. 31: 1501-1508.
Brosh, R. and V. Rotter (2009) When mutants gain new powers: news from the mutant p53 field. Nat. Rev. Cancer. 9: 701-713.
Walerych, D., M. Napoli, L. Collavin, and G. Del-Sal (2012) The rebel angel: mutant p53 as the driving oncogene in breast cancer. Carcinogenesis. 33: 2007-2017.
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