지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 149 - 158 (10page)
이용수
초록· 키워드
오류제보하기
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex etiology that encompasses immunologic responses. AD is frequently associated with elevated immunoglobulin (Ig) E levels, and common environmental factors contribute to its pathogenesis. Several recent studies have documented the role of specific lactic acid bacteria in the treatment and prevention of AD in humans and mice. In this study, the efficacy of Duolac ATP, a probiotic preparation, was determined in a mouse model with AD-like skin lesions. Alterations in the cytokine levels and histological staining suggested the alleviation of AD. The in vivo test showed that T helper (Th)2 cytokines, IgE, interleukin (IL)-4, and IL-5, were significantly downregulated, whereas Th1 cytokines, IL-12p40 and interferon (IFN)-γ, were upregulated in all groups of mice treated with Duolac ATP compared to that observed in the group of mice treated with 1-chloro-2,4-dinitrobenzene (DNCB) alone. Moreover, the scratch score decreased in all mice treated with Duolac ATP. Staining of the dorsal area of the mice in each group with hematoxylin and eosin and toluidine blue further confirmed the alleviation of AD in mice orally treated with Duolac ATP. These results suggest that Duolac ATP inhibits the development of AD-like skin lesions in NC/Nga mice by suppressing the Th2 cell response and increasing the Th1 cell response. Thus, Duolac ATP is beneficial and effective for the treatment of AD-like skin lesions.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Leung, D.Y. and Bieber, T. (2003) Atopic dermatitis. Lancet., 361, 151-160
Morar, N., Willis-Owen, S.A., Moffatt, M.F. and Cookson, W.O. (2006) The genetics of atopic dermatitis. J. Allergy Clin. Immunol., 118, 24-34
Sicherer, S.H. and Leung, D.Y. (2009) Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2008. J. Allergy Clin. Immunol., 123, 319-327
Fujiwara, D., Inoue, S., Wakabayashi, H. and Fujii, T. (2004) The anti-allergic effects of lactic acid bacteria are strain dependent and mediated by effects on both Th1/Th2 cytokine expression and balance. Int. Arch. Allergy Immunol., 135, 205- 215
Wahlgren, C.F. (1999) Itch and atopic dermatitis: an overview. J. Dermatol., 26, 770-779
Morar, N., Willis-Owen, S.A., Moffatt, M.F. and Cookson, W.O. (2006) The genetics of atopic dermatitis. J. Allergy Clin. Immunol., 118, 24-34
Sicherer, S.H. and Leung, D.Y. (2009) Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2008. J. Allergy Clin. Immunol., 123, 319-327
Fujiwara, D., Inoue, S., Wakabayashi, H. and Fujii, T. (2004) The anti-allergic effects of lactic acid bacteria are strain dependent and mediated by effects on both Th1/Th2 cytokine expression and balance. Int. Arch. Allergy Immunol., 135, 205- 215
Wahlgren, C.F. (1999) Itch and atopic dermatitis: an overview. J. Dermatol., 26, 770-779
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UCI(KEPA) : I410-ECN-0101-2016-513-002786482