지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.92 No.2
- 발행연도
- 2017.2
- 수록면
- 82 - 89 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Surgical resection of isolated hepatic or pulmonary metastases of colorectal cancer is an established procedure, with a 5-year survival rate of about 50%. However, the role of surgical resections in patients with both hepatic and pulmonary metastases is not well established. We aimed to analyze overall survival of these patients and associated factors.
Methods: Data retrospectively collected from 66 patients who underwent both hepatic and pulmonary metastasectomy after colorectal cancer surgery from August 2002 through August 2013 were analyzed. In univariate analysis, the log-rank test compared patient survival between groups. P < 0.1 was considered indicative of significance. Multivariate analysis of the significance data using a Cox proportional hazard model identified factors associated with overall survival. The synchronous group (n = 57) was defined as patients who had metastasectomy within 3 months from primary colorectal cancer surgery. The remaining nine patients constituted the metachronous group.
Results: Median follow-up was 126 months from the primary colorectal cancer surgery. The 5-year survival was 73.4%. There was no difference in overall survival between the synchronous and metachronous groups, consistent with previous studies. Distribution (involving one hemiliver or both, P = 0.010 in multivariate analysis) of liver metastases and multiplicity of the pulmonary metastasis (P = 0.039) were predictors of poor prognosis.
Conclusion: Sequential or simultaneous resection of both hepatic and pulmonary metastasis of colorectal cancer resulted in good long-term survival in selected patients. Thus, an aggressive surgical approach and multidisciplinary decision making with surgeons seems to be justified.
Methods: Data retrospectively collected from 66 patients who underwent both hepatic and pulmonary metastasectomy after colorectal cancer surgery from August 2002 through August 2013 were analyzed. In univariate analysis, the log-rank test compared patient survival between groups. P < 0.1 was considered indicative of significance. Multivariate analysis of the significance data using a Cox proportional hazard model identified factors associated with overall survival. The synchronous group (n = 57) was defined as patients who had metastasectomy within 3 months from primary colorectal cancer surgery. The remaining nine patients constituted the metachronous group.
Results: Median follow-up was 126 months from the primary colorectal cancer surgery. The 5-year survival was 73.4%. There was no difference in overall survival between the synchronous and metachronous groups, consistent with previous studies. Distribution (involving one hemiliver or both, P = 0.010 in multivariate analysis) of liver metastases and multiplicity of the pulmonary metastasis (P = 0.039) were predictors of poor prognosis.
Conclusion: Sequential or simultaneous resection of both hepatic and pulmonary metastasis of colorectal cancer resulted in good long-term survival in selected patients. Thus, an aggressive surgical approach and multidisciplinary decision making with surgeons seems to be justified.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Liu LX / 2003 / Current treatment for liver metastases from colorectal cancer / World J Gastroenterol 9 : 193 ~ 200
[학술지(정기간행물)] - Simmonds PC. / 2000 / Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis / BMJ 321 : 531 ~ 535
[단행본] - American Cancer Society. / 2015 / Cancer facts &figures / American Cancer Society
[학술지(정기간행물)] - Fong Y / 1999 / Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer : analysis of 1001 consecutive cases / Ann Surg 230 : 309 ~ 318
[학술지(정기간행물)] - Shah SA / 2007 / Survival after liver resection for metastatic colorectal carcinoma in a large population / J Am Coll Surg 205 : 676 ~ 683
[학술지(정기간행물)] - Simmonds PC. / 2000 / Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis / BMJ 321 : 531 ~ 535
[단행본] - American Cancer Society. / 2015 / Cancer facts &figures / American Cancer Society
[학술지(정기간행물)] - Fong Y / 1999 / Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer : analysis of 1001 consecutive cases / Ann Surg 230 : 309 ~ 318
[학술지(정기간행물)] - Shah SA / 2007 / Survival after liver resection for metastatic colorectal carcinoma in a large population / J Am Coll Surg 205 : 676 ~ 683
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UCI(KEPA) : I410-ECN-0101-2017-514-002372265