지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.93 No.1
- 발행연도
- 2017.7
- 수록면
- 50 - 56 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Postoperative intraperitoneal adhesions (PIAs) are one of the most important problems surgeons have to face after laparotomies. In this study, we aimed to evaluate the effectiveness of local application of botulinum toxin type A (BoNT-A) in various dosages on the prevention of intra-abdominal adhesions in rats with experimental intra-abdominal adhesions.
Methods: Forty Wistar Albino female rats were randomly separated into 4 groups. The 4 groups were determined as follows: Control (group 1, n = 10); Sham (group 2, n = 10); 10-mg/kg low-dose BoNT-A (group 3, n = 10) and 30-㎎/㎏ highdose BoNT-A (group 4, n = 10). Subserosal injuries were created on the caecum of all rats. Laparotomy was performed on the fifth day. Adhesion scores, histopathological examination, and E-cadherin expression levels were evaluated.
Results: General adhesion scores for groups 1 and 2 were determined to be significantly high when compared to group 4 (P ＜ 0.001). A significant difference was also determined between groups 3 and 4 in terms of general adhesion scores (P ＜ 0.05). In pair comparisons, a significant decrease in high-dose BoNT-A group (group 4) when compared to groups 1 and 2 in terms of neovascularization, fibroblast density, collagen deposition and inflammatory cell count was determined (P ＜ 0.05).
Conclusion: A significant decrease was observed only in postoperative PIAs in the high-dose BoNT-A group between all 4 rat-groups with experimentally created postoperative PIAs. In this study, high-dose BoNT-A is determined to be an effective agent in preventing postoperative PIAs.
Methods: Forty Wistar Albino female rats were randomly separated into 4 groups. The 4 groups were determined as follows: Control (group 1, n = 10); Sham (group 2, n = 10); 10-mg/kg low-dose BoNT-A (group 3, n = 10) and 30-㎎/㎏ highdose BoNT-A (group 4, n = 10). Subserosal injuries were created on the caecum of all rats. Laparotomy was performed on the fifth day. Adhesion scores, histopathological examination, and E-cadherin expression levels were evaluated.
Results: General adhesion scores for groups 1 and 2 were determined to be significantly high when compared to group 4 (P ＜ 0.001). A significant difference was also determined between groups 3 and 4 in terms of general adhesion scores (P ＜ 0.05). In pair comparisons, a significant decrease in high-dose BoNT-A group (group 4) when compared to groups 1 and 2 in terms of neovascularization, fibroblast density, collagen deposition and inflammatory cell count was determined (P ＜ 0.05).
Conclusion: A significant decrease was observed only in postoperative PIAs in the high-dose BoNT-A group between all 4 rat-groups with experimentally created postoperative PIAs. In this study, high-dose BoNT-A is determined to be an effective agent in preventing postoperative PIAs.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Ouaissi M / 2012 / Post-operative adhesions after digestive surgery: their incidence and prevention: review of the literature / J Visc Surg 149 : e104 ~ e114
[학술지(정기간행물)] - Takagi K / 2013 / Novel powdered anti-adhesion material : preventing postoperative intra-abdominal adhesions in a rat model / Int J Med Sci 10 : 467 ~ 474
[학술지(정기간행물)] - Ray NF / 1998 / Abdominal adhesiolysis : inpatient care and expenditures in the United States in 1994 / J Am Coll Surg 186 : 1 ~ 9
[학술지(정기간행물)] - Gokhan Karaca / 2016 / Effect of ankaferd blood stopper in experimental peritoneal adhesion model / 대한외과학회지 90 (4) : 213 ~ 217
[학술지(정기간행물)] - Kirdak T / 2008 / Assessment of effectiveness of different doses of methylprednisolone on intraabdominal adhesion prevention / Ulus Travma Acil Cerrahi Derg 14 : 188 ~ 191
[학술지(정기간행물)] - Takagi K / 2013 / Novel powdered anti-adhesion material : preventing postoperative intra-abdominal adhesions in a rat model / Int J Med Sci 10 : 467 ~ 474
[학술지(정기간행물)] - Ray NF / 1998 / Abdominal adhesiolysis : inpatient care and expenditures in the United States in 1994 / J Am Coll Surg 186 : 1 ~ 9
[학술지(정기간행물)] - Gokhan Karaca / 2016 / Effect of ankaferd blood stopper in experimental peritoneal adhesion model / 대한외과학회지 90 (4) : 213 ~ 217
[학술지(정기간행물)] - Kirdak T / 2008 / Assessment of effectiveness of different doses of methylprednisolone on intraabdominal adhesion prevention / Ulus Travma Acil Cerrahi Derg 14 : 188 ~ 191
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UCI(KEPA) : I410-ECN-0101-2018-514-000991911