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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Mitogen-activated protein kinase (MAPK) signaling pathways play a key role in innate immunity, inflammation, cell proliferation, cell differentiation, and cell death. The main objective of this study was to investigate the expression level of candidate MAPK pathway genes in the intestinal mucosal layer of two genetically disparate chicken lines (Marek’s diseaseresistant line 6.3 and Marek’s disease-susceptible line 7.2) induced with necrotic enteritis (NE). Using high-throughput RNA sequencing, we investigated 178 MAPK signaling pathway related genes that were significantly and differentially expressed between the intestinal mucosal layers of the NE-afflicted and control chickens. In total, 15 MAPK pathway genes were further measured by quantitative real-time PCR(qRT-PCR) and the results were consistent with the RNA-sequencing data. All 178 identified genes were annotated through Gene Ontology and mapped onto the KEGG chicken MAPK signaling pathway. Several key genes of the MAPK pathway, ERK1/2, JNK1-3, p38 MAPK, MAP2K1-4, NF-κB1/2, c-Fos, AP-1, Jun-D, and Jun, were differentially expressed in the two chicken lines. Therefore, we believe that RNA sequencing and qRT-PCR analysis provide resourceful information for future studies on MAPK signaling of genetically disparate chicken lines in response to pathogens.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Andrus L / 2011 / Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells / Hepatology (Baltimore, Md.) 54 (6) : 1901 ~ 1912
[학술지(정기간행물)] - Cargnello M / 2011 / Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases / Microbiol Mol Biol Rev 75 (1) : 50 ~ 83
[학술지(정기간행물)] - Chen J / 2014 / The effect of lycopene on the PI3K/Akt signalling pathway in prostate cancer / Anticancer Agents Med Chem 14 (6) : 800 ~ 805
[학술지(정기간행물)] - Das D / 2013 / TGF-beta1-induced MAPK activation promotes collagen synthesis, nodule formation, redox stress and cellular senescence in porcine aortic valve interstitial cells / J Heart Valve Dis 22 (5) : 621 ~ 630
[학술지(정기간행물)] - Das KC / 2010 / c-Jun-NH2 terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: Phosphorylation of cJun, JunB, and Fra-1 / Mol Cell Biochem 337 (1-2) : 53 ~ 63
[학술지(정기간행물)] - Cargnello M / 2011 / Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases / Microbiol Mol Biol Rev 75 (1) : 50 ~ 83
[학술지(정기간행물)] - Chen J / 2014 / The effect of lycopene on the PI3K/Akt signalling pathway in prostate cancer / Anticancer Agents Med Chem 14 (6) : 800 ~ 805
[학술지(정기간행물)] - Das D / 2013 / TGF-beta1-induced MAPK activation promotes collagen synthesis, nodule formation, redox stress and cellular senescence in porcine aortic valve interstitial cells / J Heart Valve Dis 22 (5) : 621 ~ 630
[학술지(정기간행물)] - Das KC / 2010 / c-Jun-NH2 terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: Phosphorylation of cJun, JunB, and Fra-1 / Mol Cell Biochem 337 (1-2) : 53 ~ 63
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UCI(KEPA) : I410-ECN-0101-2018-527-001355627