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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 375 - 381 (7page)
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초록· 키워드
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Background: We evaluated the drug interaction profile of Red Ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers.
Methods: This article describes an open-label, crossover study. CYP probe cocktail drugs, caffeine, losartan, dextromethorphan, omeprazole, midazolam, and fexofenadine were administered before and after RG supplementation for 2 wk. Plasma samples were collected, and tolerability was assessed. Pharmacokinetic parameters were calculated, and 90% confidence intervals (CIs) of the geometric mean ratios of the parameters were determined from logarithmically transformed data using analysis of variance after RG administration versus before RG administration.
Results: Fourteen healthy male participants were evaluated, none of whom were genetically defined as poor CYP2C9, 2C19, and CYP2D6 metabolizers based on genotyping. Before and after RG administration, the geometric least-square mean metabolic ratio (90% CI) was 0.870 (0.805e0.940) for caffeine to paraxanthine (CYP1A2), 0.871 (0.800e0.947) for losartan (CYP2C9) to EXP3174, 1.027 (0.938e1.123) for omeprazole (CYP2C19) to 5-hydroxyomeprazole, 1.373 (0.864e2.180) for dextromethorphan to dextrorphan (CYP2D6), and 0.824 (0.658e1.032) for midazolam (CYP3A4) to 1-hydroxymidazolam. The geometric mean ratio of the area under the curve of the last sampling time (AUC<SUB>last</SUB>) for fexofenadine (P-gp) was 0.963 (0.845e1.098). Administration of concentrated RG for 2 wk weakly inhibited CYP2C9 and CYP3A4 and weakly induced CYP2D6. However, no clinically significant drug interactions were observed between RG and CYP and P-gp probe substrates.
Conclusion: RG has no relevant potential to cause CYP enzyme- or P-gp-related interactions.
Methods: This article describes an open-label, crossover study. CYP probe cocktail drugs, caffeine, losartan, dextromethorphan, omeprazole, midazolam, and fexofenadine were administered before and after RG supplementation for 2 wk. Plasma samples were collected, and tolerability was assessed. Pharmacokinetic parameters were calculated, and 90% confidence intervals (CIs) of the geometric mean ratios of the parameters were determined from logarithmically transformed data using analysis of variance after RG administration versus before RG administration.
Results: Fourteen healthy male participants were evaluated, none of whom were genetically defined as poor CYP2C9, 2C19, and CYP2D6 metabolizers based on genotyping. Before and after RG administration, the geometric least-square mean metabolic ratio (90% CI) was 0.870 (0.805e0.940) for caffeine to paraxanthine (CYP1A2), 0.871 (0.800e0.947) for losartan (CYP2C9) to EXP3174, 1.027 (0.938e1.123) for omeprazole (CYP2C19) to 5-hydroxyomeprazole, 1.373 (0.864e2.180) for dextromethorphan to dextrorphan (CYP2D6), and 0.824 (0.658e1.032) for midazolam (CYP3A4) to 1-hydroxymidazolam. The geometric mean ratio of the area under the curve of the last sampling time (AUC<SUB>last</SUB>) for fexofenadine (P-gp) was 0.963 (0.845e1.098). Administration of concentrated RG for 2 wk weakly inhibited CYP2C9 and CYP3A4 and weakly induced CYP2D6. However, no clinically significant drug interactions were observed between RG and CYP and P-gp probe substrates.
Conclusion: RG has no relevant potential to cause CYP enzyme- or P-gp-related interactions.
목차
ABSTRACT
1. Introduction
2. Methods
3. Results
4. Discussion
5. Conclusion
References
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Choi KT / 2008 / Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer / Acta Pharmacol Sin 29 : 1109 ~ 1118
[학술지(정기간행물)] - 공병만 / 2008 / 백삼, 발효인삼, 홍삼 농축액의 이화학적 특성 / Journal of Ginseng Research 32 (3) : 238 ~ 243
[학술지(정기간행물)] - Qi LW / 2011 / Metabolism of ginseng and its interactions with drugs / Curr Drug Metab 12 : 818 ~ 822
[학술지(정기간행물)] - Henderson GL / 1999 / Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity / Life Sci 65 : PL209 ~ PL214
[학술지(정기간행물)] - Yu CT / 2005 / Lack of evidence for induction of CYP2B1, CYP3A23, and CYP1A2 gene expression by Panax ginseng and Panax quinquefolius extracts in adult rats and primary cultures of rat hepatocytes / Drug Metab Dispos 33 : 19 ~ 22
[학술지(정기간행물)] - 공병만 / 2008 / 백삼, 발효인삼, 홍삼 농축액의 이화학적 특성 / Journal of Ginseng Research 32 (3) : 238 ~ 243
[학술지(정기간행물)] - Qi LW / 2011 / Metabolism of ginseng and its interactions with drugs / Curr Drug Metab 12 : 818 ~ 822
[학술지(정기간행물)] - Henderson GL / 1999 / Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity / Life Sci 65 : PL209 ~ PL214
[학술지(정기간행물)] - Yu CT / 2005 / Lack of evidence for induction of CYP2B1, CYP3A23, and CYP1A2 gene expression by Panax ginseng and Panax quinquefolius extracts in adult rats and primary cultures of rat hepatocytes / Drug Metab Dispos 33 : 19 ~ 22
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UCI(KEPA) : I410-ECN-0101-2018-524-001598507