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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 86 - 99 (14page)
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IL-15 is a cytokine of the common γ-chain family that is critical for natural killer (NK), invariant natural killer T (iNKT), and CD8 memory T cell development and homeostasis. The role of IL-15 in regulating effector T cell subsets, however, remains incompletely understood. IL-15 is mostly expressed by stromal cells, myeloid cells, and dendritic cells (DCs). Whether T cells themselves can express IL-15, and if so, whether such T cell-derived IL-15 could play an autocrine role in T cells are interesting questions that were previously addressed but answered with mixed results. Recently, three independent studies described the generation of IL-15 reporter mice which facilitated the identification of IL-15-producing cells and helped to clarify the role of IL-15 both in vitro and in vivo. Here, we review the findings of these studies and place them in context of recent reports that examined T cell-intrinsic IL-15 expression during CD4 effector T cell differentiation.
목차
ABSTRACT
INTRODUCTION
EXPRESSION AND TRANS-PRESENTATION OF IL-15
GENERATION AND CHARACTERIZATION OF IL-15REPORTER MICE
IL-15 EXPRESSION IN NON-LYMPHOID STROMAL ANDEPITHELIAL CELLS
IL-15 EXPRESSION BY DENDRITIC CELLS
IL-15 EXPRESSION BY T CELLS
CONCLUSION AND PERSPECTIVE
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2018-517-001801175