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논문 기본 정보

자료유형
학술저널
저자정보
Ki Hyun Kim (Sungkyunkwan University) Dahae Lee (Sungkyunkwan University) Hye Lim Lee (Gachon University) Chang-Eop Kim (Gachon University) Kiwon Jung (CHA University) Ki Sung Kang (Gachon University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.42 No.3
발행연도
2018.6
수록면
239 - 247 (9page)

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초록· 키워드

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In recent years, several therapeutic drugs have been rationally designed and synthesized based on the novel knowledge gained from investigating the actions of biologically active chemicals derived from foods, plants, and medicinal herbs. One of the major advantages of these naturalistic chemicals is their ability to interact with multiple targets in the body resulting in a combined beneficial effect. Ginseng is a perennial herb (Araliaceae family), a species within the genus Panax, and a highly valued and popular medicinal plant. Evidence for the medicinal and health benefits of Panax ginseng and its components in preventing neurodegeneration has increased significantly in the past decade. The beneficial effects of P. ginseng on neurodegenerative diseases have been attributed primarily to the antioxidative and immunomodulatory activities of its ginsenoside components. Mechanistic studies on the neuroprotective effects of ginsenosides revealed that they act not only as antioxidants but also as modulators of intracellular neuronal signaling and metabolism, cell survival/death genes, and mitochondrial function. The goal of the present paper is to provide a brief review of recent knowledge and developments concerning the beneficial effects as well as the mechanism of action of P. ginseng and its components in the treatment and prevention of neurodegenerative diseases.

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ABSTRACT
1. Introduction
2. Basic and clinical evidence on the beneficial effects of P. ginseng on neurodegenerative diseases
3. Concluding remarks and future perspectives
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UCI(KEPA) : I410-ECN-0101-2018-524-003161099