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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 157 - 167 (11page)
이용수
초록· 키워드
오류제보하기
The concept of gene therapy is to treat a disease by transferring therapeutic nucleic acids to a patient"s cells. It took several decades from the basic theoretical proposal of gene therapy to the current promising treatment option for some important human diseases. The encountered adverse effects in the early clinical studies boosted the development of sophisticated vectors and elaborate clinical designs. The gene therapy is now considered to have the potential to cure many diseases that are incurable with conventional medications. By the end of 2017, about 2,600 clinical trials of gene therapy have been performed or are ongoing for a variety of diseases such as cancers, monogenic diseases, cardiovascular diseases and neurological diseases etc. Here, we present a brief introduction of technical achievement in relation to gene therapy development, and a review of the current status of global gene therapy clinical development.
목차
서론
유전자치료제 개발의 기술적 기반
유전자치료제의 임상개발과 시판 승인
유전자치료제의 임상개발 현황
결론 및 논의
REFERENCES
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Abbasi J / 2018 / Biotech Innovations. Clinical Advances in Human Gene Therapies / JAMA 319 : 113 ~
[학술지(정기간행물)] - Ameri H / 2018 / Prospect of retinal gene therapy following commercialization of voretigene neparvovec-rzyl for retinal dystrophy mediated by RPE65 mutation / J Curr Ophthalmol 30 : 1 ~ 2
[학술지(정기간행물)] - Blaese RM / 1995 / T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years / Science 270 : 475 ~ 480
[단행본] - Choi JW / 2017 / What is virus to cancer? Two strategies to treat cancers / Biospectator
[인터넷자원] - ClinicalTrials.gov homepage / 2018 / ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world
[학술지(정기간행물)] - Ameri H / 2018 / Prospect of retinal gene therapy following commercialization of voretigene neparvovec-rzyl for retinal dystrophy mediated by RPE65 mutation / J Curr Ophthalmol 30 : 1 ~ 2
[학술지(정기간행물)] - Blaese RM / 1995 / T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years / Science 270 : 475 ~ 480
[단행본] - Choi JW / 2017 / What is virus to cancer? Two strategies to treat cancers / Biospectator
[인터넷자원] - ClinicalTrials.gov homepage / 2018 / ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world
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UCI(KEPA) : I410-ECN-0101-2018-510-003599288