지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 213 - 220 (8page)
이용수
초록· 키워드
오류제보하기
Triglyceride (TG) is known to be associated with inflammatory disease including atherosclerosis. In a variety of atherosclerosis models, T lymphocytes are localized in the earliest lesions of atherosclerosis. T cell associated cytokines such as TNF-α and IFN-γ have pre-dominant inflammatory effects in chronic vascular diseases. In our previous study, we found that the expression of TNF-α and its receptor, TNF-αR was increased when Jurkat T lymphocyte cell lines were exposed to TGs. Therefore, experiments were conducted to determine which cell signaling pathway are involved in the increase of TNF-α and TNF-αR expression by TGs. To identify signal transduction pathways involved in TG-induced upregulation of TNF-α, we treated TG-exposed Jurkat T cells with specific inhibitors for MEK1, PI3K, NF-κB and PKC. We found that inhibition of the MEK1 pathway blocked TG-induced upregulation of TNF-α. However, the expression level of TNF-αR did not change with any signal transduction inhibitor. Based on this observation, we suggest that increase of exogenous TG induces increase of TNF-α expression through MEK1 pathway in Jurkat T cells. In addition, it was confirmed that the increase of TNF-α and TNF-αR expression by TGs occurs via different pathways.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - Ajizian SJ / 1999 / Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma / J Infect Dis 179 : 939 ~ 944
[학술지(정기간행물)] - Aronis A / 2009 / Triacylglycerolinduced impairment in mitochondrial biogenesis and function in j774.2 and mouse peritoneal macrophage foam cells / Arch Biochem Biophys 492 : 74 ~ 81
[학술지(정기간행물)] - Aronis A / 2005 / Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of j774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis / Free Radic Biol Med 38 : 1221 ~ 1230
[학술지(정기간행물)] - Boulton TG / 1991 / Erks: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and ngf / Cell 65 : 663 ~ 675
[학술지(정기간행물)] - Burger D / 2002 / The role of human t-lymphocyte-monocyte contact in inflammation and tissue destruction / Arthritis Res 4 (Suppl 3) : S169 ~ S176
[학술지(정기간행물)] - Aronis A / 2009 / Triacylglycerolinduced impairment in mitochondrial biogenesis and function in j774.2 and mouse peritoneal macrophage foam cells / Arch Biochem Biophys 492 : 74 ~ 81
[학술지(정기간행물)] - Aronis A / 2005 / Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of j774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis / Free Radic Biol Med 38 : 1221 ~ 1230
[학술지(정기간행물)] - Boulton TG / 1991 / Erks: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and ngf / Cell 65 : 663 ~ 675
[학술지(정기간행물)] - Burger D / 2002 / The role of human t-lymphocyte-monocyte contact in inflammation and tissue destruction / Arthritis Res 4 (Suppl 3) : S169 ~ S176
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UCI(KEPA) : I410-ECN-0101-2018-510-003599344