지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.45 No.3
- 발행연도
- 2018.9
- 수록면
- 509 - 519 (11page)
이용수
초록· 키워드
오류제보하기
This study was investigated the anti-oxidant property and neuro-protective effect of Cirsium japonicum var. maackii (CJM) against oxidative stress in hydrogen peroxide (H₂O₂)-induced C6 glial cells. We measured the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydroxyl radical (·OH), and superoxide (O₂<SUP>-</SUP>) radical scavenging activities of an ethanol extract and four fractions [n -Butanol, ethyl acetate (EtOAc), CHC<SUP>l3</SUP>, and n -Hexane] from CJM. The results of this study show that the extract and all fractions from CJM had a dose-dependent DPPH radical scavenging activity. In particular, the EtOAc fraction exhibited the strongest scavenging effect with 88.23% at a concentration of 500 μg/mL. In addition, the EtOAc fraction from CJM also effectively scavenged ·OH radicals and O₂<SUP>-</SUP> radicals, compared to other extract and fractions. In C6 glial cells, H₂O₂ markedly decreased the cell viability as well as increased lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) production. However, the EtOAc fraction of CJM attenuated the cellular damage from the oxidative stress by elevating the cell viability and inhibiting the LDH release and ROS over-production compared with the H₂O₂-treated control group. Our findings indicate that the EtOAc fraction from CJM has antioxidant effect and neuro-protective effect against oxidative stress, suggesting that it can be used as a natural antioxidant and therapeutic agent for the prevention of neurodegenerative disorders.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References
참고문헌 (50)
참고문헌 신청
[학술지(정기간행물)] - Bamham KJ / 2004 / Neurodegenerative diseases and oxidative stress / Nature Reviews Drugs Discovery 3 : 205 ~ 214
[학술지(정기간행물)] - Behl C / 1999 / Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches / Progress in Neurobiology 57 : 301 ~ 323
[학술지(정기간행물)] - Block ML / 2005 / Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism / Progress in Neurobiology 76 : 77 ~ 98
[학술지(정기간행물)] - Cathcart R / 1983 / Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay / Analytical Biochemisry 134 : 111 ~ 116
[학술지(정기간행물)] - 최장숙 / 2003 / 밤꽃(Castanea Crenata Flos.) 메탄올 추출물의 항산화 효과 / 한국식품과학회지 35 (6) : 1216 ~ 1220
[학술지(정기간행물)] - Behl C / 1999 / Alzheimer's disease and oxidative stress: Implications for novel therapeutic approaches / Progress in Neurobiology 57 : 301 ~ 323
[학술지(정기간행물)] - Block ML / 2005 / Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism / Progress in Neurobiology 76 : 77 ~ 98
[학술지(정기간행물)] - Cathcart R / 1983 / Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay / Analytical Biochemisry 134 : 111 ~ 116
[학술지(정기간행물)] - 최장숙 / 2003 / 밤꽃(Castanea Crenata Flos.) 메탄올 추출물의 항산화 효과 / 한국식품과학회지 35 (6) : 1216 ~ 1220
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Antioxidant effects of Cirsium japonicum var. maackii on oxidative stress in C6 glial cells and mice
Korean Journal of Agricultural Science
2022 .03
-
Cirsium japonicum var. maackii inhibits hydrogen peroxide-induced oxidative stress in SH-SY5Y cells
Korean Journal of Agricultural Science
2021 .03
-
Protective effects of Cirsium japonicum var. maackii against amyloid beta-induced neurotoxicity in C6 glial cells
Korean Journal of Agricultural Science
2019 .06
-
Free radical scavenging activity of Cirsium japonicum var. maackii flower
Korean Journal of Agricultural Science
2023 .03
-
Neuroprotective Effects of Flower from Cirsium japonicum var. maackii against H₂O₂-induced C6 Glial Cells
한국식품영양과학회 학술대회발표집
2024 .10
-
Protective Role of Kimchi under Different Fermentation Stages from Oxidative Stress in C6 Glial Cell
한국식품영양과학회 학술대회발표집
2018 .10
-
Protective Effects against Cognitive Impairment by Cirsium japonicum var. maackii Flower on the Role of Gut-Brain Axis
한국식품영양과학회 학술대회발표집
2023 .10
-
Protective Effects of Cirsium Japonicum var. maackii on the Arthritis and the Qualitative Analyses of Water Extracts
한국약용작물학회 학술대회논문집
2018 .05
-
H₂O₂로 유도된 C6 신경교세포의 세포사멸에 대한 감초 추출물과 감초 활성물질의 보호효과
한국약용작물학회지
2017 .10
-
Immunostimulatory Activity of Cirsium japonicum var. maackii Derived-Natural Substances in RAW 264.7 Mouse Macrophages
한국식품영양과학회 학술대회발표집
2023 .10
-
Immunomodulatory Effects of Cirsium japonicum var. maackii-derived Flavone Components on Natural Killer Cell Activity and Apoptotic Pathways
한국식품영양과학회 학술대회발표집
2024 .10
-
Cirsium japonicum var. maackii Extract Suppress Vascular Adhesion Factor Expression in TNF-α-treated Human Vascular Endothelial Cells by Inhibiting NF-κB Activation
한국식품영양과학회 학술대회발표집
2022 .10
-
Immune-enhancing effects of Pediococcus pentosaceus-Cirsium japonicum var. maackii fermentation
한국식품영양과학회 학술대회발표집
2022 .10
-
Antioxidant effect of Moringa ethanol extract and protective effect against oxidative stress induced by hydrogen peroxide in SH-SY5Y cells
한국식품영양과학회 학술대회발표집
2021 .10
-
Effect of Donganme (Sorghum bicolor L. Moench) against oxidative stress in vitro and in a cellular system in glial cells
Korean Journal of Agricultural Science
2020 .09
-
좁은잎 엉겅퀴 추출물의 산화방지 활성 및 산화적 스트레스에 대한 PC12 세포 보호효과
한국식품과학회지
2016 .04
-
Radical scavenging activity of ethanol extract and solvent partitioned fractions of lotus seeds
Korean Journal of Agricultural Science
2016 .06
-
우산고로쇠의 항산화 및 신경세포에서의 산화적 스트레스 개선 효과
Journal of applied biological chemistry
2017 .01
-
Inflammatory Protective and Improvement Effects of Ethanolic Extracts from Cirsium japonicum var. ussuriense in LPSstimulated RAW264.7 cells
한국식품영양과학회 학술대회발표집
2015 .08
-
산화스트레스와 치매
Journal of Dairy Science and Biotechnology
2020 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
IoT환경에 대한 블록체인과 탱글의 비교분석
우상호
,
이상길
,
신재권
외 2명
한국통신학회 학술대회논문집
2019
.01
“초지능 시대와 미래” 특집을 내면서
임광혁
한국콘텐츠학회지
2019
.03
초연결(IoT) 초지능(AI) 시대에 요구되는 인재는?
김현수
한국자동차공학회 Workshop
2018
.08
API-call Constraint Checking Considering Alarms and ISRs for IoT Device Control Software
김동우
,
최윤자
Journal of KIISE
2018
.12
[특집편집기] Neuromorphic 시스템 설계 기술
김영민
전자공학회지
2018
.07
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-520-003591408