지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 364 - 374 (11page)
- DOI
- 10.17495/easdl.2018.8.28.5.364
이용수
초록· 키워드
오류제보하기
This research was conducted to determine the impact of high sodium intake on various obesity-related genes. Four week old Sprague-Dawley rats were purchased at Daehan Biolink. After one week of fertilization, the rats were used at 5 weeks of age. Rats were divided into three groups that received sodium orally at 0 mM(CON), 100 mM(Salt-100 mM), or 400 mM(Salt-400 mM). After 3 weeks, rats were sacrificed and used in the experiment. Triglycerides (TG) and total cholesterol (TC) were measured in the blood serum and liver. The activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were analyzed to test the hepatic toxicity. Genes related to lipogenesis and adipogenesis, uncoupling protein1 (UCP1), and tumor necrosis factor-alpha (TNF-α) were expressed in the liver, white adipose tissue (WAT) and brown adipose tissue (BAT). The levels of albumin and creatinine were measured in the urine. The TG and TC levels in blood serum were highest in the Salt-100 mM group, while liver TG and TC were highest in the Salt-400 mM group. Lipogenesis and adipogenesis related genes in the liver did not increase proportionally to salt concentration. In visceral and subcutaneous fat, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα) were upregulated proportionally with increasing sodium levels. These results suggest that high sodium intake provoked adipogenesis in SD rats. In BAT, the expression of UCP1 was lower in the Salt-400 mM group than the CON group. Additionally, TNF-α in visceral fat and urine albumin and creatinine were higher in salt treated groups than the CON group. Overall, the results indicate that high sodium intake may be associated with obesity and complications.
목차
ABSTRACT
서론
재료 및 방법
결과 및 고찰
요약 및 결론
REFERENCES
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Baracho NCD / 2016 / Characterization of an experimental model of progressive renal disease in rats / Acta Cir Bras 31 (11) : 744 ~ 752
[학술지(정기간행물)] - Borst SE / 2005 / High-fat diet induces increased tissue expression of $TNF-{\alpha}$ / Life Sci 77 (17) : 2156 ~ 2165
[학술지(정기간행물)] - Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 (1-2) : 248 ~ 254
[학술지(정기간행물)] - 차봉수 / 2006 / 인슐린 저항성과 PPARγ / Diabetes and Metabolism Journal 30 (5) : 317 ~ 323
[학술지(정기간행물)] - 천세영 / 2017 / 2010년~2014년 국민건강영양조사 자료를 이용한 성인의 나트륨 섭취와 비만과의 관련성 / Journal of Nutrition and Health 50 (1) : 64 ~ 73
[학술지(정기간행물)] - Borst SE / 2005 / High-fat diet induces increased tissue expression of
[학술지(정기간행물)] - Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 (1-2) : 248 ~ 254
[학술지(정기간행물)] - 차봉수 / 2006 / 인슐린 저항성과 PPARγ / Diabetes and Metabolism Journal 30 (5) : 317 ~ 323
[학술지(정기간행물)] - 천세영 / 2017 / 2010년~2014년 국민건강영양조사 자료를 이용한 성인의 나트륨 섭취와 비만과의 관련성 / Journal of Nutrition and Health 50 (1) : 64 ~ 73
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Relationship of sodium index with the obesity indicators of university students in Daegu, South Korea: a cross-sectional study
대한지역사회영양학회지
2024 .06
-
비만인과 정상인에서 24시간 소변 내 나트륨 배출량과 비만관련 대사위험지표의 관련성
대한지역사회영양학회지
2015 .12
-
The association between dietary sodium intake and obesity in adults by sodium intake assessment methods: a review of systematic reviews and re-meta-analysis
Nutrition Research and Practice
2023 .04
-
The association between dietary sodium intake and obesity in adults by sodium intake assessment methods: a review of systematic reviews and re-meta-analysis
Nutrition Research and Practice
2023 .04
-
Development and application of the sodium index to estimate and assess sodium intake for Korean adults
Nutrition Research and Practice
2022 .06
-
Development and application of the sodium index to estimate and assess sodium intake for Korean adults
Nutrition Research and Practice
2022 .06
-
소금민감성유전자와 비만
Journal of Nutrition and Health
2017 .06
-
대학생의 나트륨 관련 영양지식과 식행동 및 나트륨 급원식품 섭취빈도 조사
동아시아식생활학회지
2015 .02
-
근거 기반 나트륨 저감 건강 식생활 프로그램의 리빙랩 모델 적용
대한지역사회영양학회지
2025 .02
-
중학생의 나트륨 과다섭취 식행동과 저염식 실천에 대한 인식실태
과학논집
2016 .02
-
사회인지론에 근거한 나트륨 섭취 줄이기 소비자 영양교육 프로그램의 효과 평가
대한지역사회영양학회지
2015 .12
-
군인의 나트륨 섭취와 나트륨 줄이기 관련 지식 및 실천에 관한 연구
동아시아식생활학회지
2016 .12
-
광주지역 성인의 나트륨 배설량과 비만의 관계
대한지역사회영양학회지
2018 .02
-
Trends in sodium intake and major contributing food groups and dishes in Korea: the Korea National Health and Nutrition Examination Survey 2013–2017
Nutrition Research and Practice
2021 .06
-
Trends in sodium intake and major contributing food groups and dishes in Korea: the Korea National Health and Nutrition Examination Survey 2013–2017
Nutrition Research and Practice
2021 .06
-
Effect of sodium restriction on blood pressure of unstable or uncontrolled hypertensive patients in primary care
Nutrition Research and Practice
2015 .04
-
Effect of sodium restriction on blood pressure of unstable or uncontrolled hypertensive patients in primary care
Nutrition Research and Practice
2015 .04
-
부산지역 대학생의 나트륨 섭취량에 따른 식생활 비교
한국지역사회생활과학회지
2015 .02
-
Korean solar salts reduce obesity and alter its related markers in diet-induced obese mice
Nutrition Research and Practice
2016 .12
-
Sodium intake trend and current intake level by meal provision place among the citizens of Seoul
Nutrition Research and Practice
2023 .06
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-594-000038117