지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Human breast milk (HBM) provides neonates with indispensable nutrition. The present study evaluated the anti-cancer activity of diluted and pasteurized early HBM (< 6 weeks’ lactation) on human breast cancer cell lines. The cell lines MCF7 and MDA-MB231 were exposed to 1% HBM from the 1st, 3rd, and 6th weeks of lactation and exhibited reduced proliferation rates. As controls, breast cell lines (293T and MCF-10A), breast cancer cell lines (MCF-7 and MDA-MB-231), and CD133<SUP>hi</SUP>CXCR4<SUP>hi</SUP>ALDH1<SUP>hi</SUP> patient-derived human cancer stem-like cells (KUCSLCs) were treated with prominent milk proteins β-casein, κ-casein, and lactoferrin at varying doses (10, 50, and 100 μg) for 24 or 48 hrs. The impact of these proteins on cell proliferation was investigated. Breast cancer cell lines treated with κ-casein and lactoferrin exhibited significantly reduced viability, in both a dose- and time-dependent manner. Interestingly, κ-casein selectively impacted only cancer (but not normal breast) cell lines, particularly the more malignant cell line. However, β-casein-exposed human breast cancer cell lines exhibited a significantly higher proliferation rate. Thus, κ-casein and lactoferrin appear to exert selective anti-cancer activities. Further studies are warranted to determine the mechanisms underlying κ-casein- and lactoferrin-mediated cancer cell-selective cytotoxic effects.
목차
Abstract
1. Introduction
2. Methods and Materials
3. Results
4. Discussion
References
참고문헌 (25)
참고문헌 신청
O. Hallgren, S. Aits, P. Brest, L. Gustafsson, A. K. Mossberg, B. Wullt, and C. Svanborg, Adv. Exp. Med. Biol., 606, 217-240 (2008).
A. do Carmo Franca-Botelho, M. C. Ferreira, J. L. Franca, E. L. Franca, and A. C. Honorio-Franca, Asian. Pac. J. Cancer. Prev., 13(11), 5327-5332 (2012).
Y. Zhou, J. Chen, Q. Li, W. Huang, H. Lan, and H. Jiang, Breastfeed. Med., 10(3), 175-182 (2015).
S. S. Hasson, J. Z. Al-Busaidi, Z. A. Al-Qarni, S. Rajapakse, S. Al-Bahlani, M. A. Idris, and T. A. Sallam, Asian. Pac. J. Cancer. Prev., 16(15), 6651-6661 (2015).
H. M. Korashy, Z. H. Maayah, A. R. Abd-Allah, A. O. El-Kadi, and A. A. Alhaider, J. Biomed. Biotechnol., 2012, 593195 (2012).
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
카세인과 아가검이 첨가된 냉동 저장 가래떡의 품질 특성
과학논집
2017 .02
-
Lactoferrin Protects Human Mesenchymal Stem Cells from Oxidative Stress-Induced Senescence and Apoptosis
Journal of Microbiology and Biotechnology
2017 .01
-
Molecular fossils “pseudogenes” as functional signature in biological system
Genes & Genomics
2020 .01
-
Optimization of LC-MS/MS method in Health Functional Food Code: Quantitative measurement of αS1-casein with modified LC condition
한국분석과학회 학술대회
2023 .05
-
Study of mitochondria depolarization by plasma activated medium on cancer cell lines
한국진공학회 학술발표회초록집
2021 .02
-
다차원적 신체이미지, 자아존중감과 의복추구혜택에 관한 연구 : 유방암 생존자와 일반여성의 비교를 중심으로
한국생활과학회지
2016 .12
-
Hispidulin이 유방암 및 유방암 줄기세포에 미치는 영향 연구
한국지역사회생활과학회지
2022 .11
-
3D Wave of Fermented Soybean Extracts Suppress Proliferation of Human Breast Cancer MDA-MB-231 Cells
한국미생물학회 학술대회논문집
2016 .04
-
The Analysis of Human Microbiome as a Cause of Breast Cancer at a Young Age
한국미생물학회 학술대회논문집
2022 .10
-
Association between Long-term Exposure to Particulate Matter and Cause-specific Cancer Incidence Using Cancer Screenee Cohort of the National Cancer Center in South Korea
한국대기환경학회 학술대회논문집
2023 .10
-
Elucidating the Roles of the Casein Kinase 2 Complex in the Growth, Differentiation, Stress Responses, and Pathogenicity of Cryptococcus neoformans
한국미생물학회 학술대회논문집
2022 .10
-
곰보배추 추출물의 항산화 활성 및 MCF-7 유방암세포에서의 Apoptosis 유도 효과
한국지역사회생활과학회지
2018 .05
-
익모초 추출물의 항산화 효과 및 MCF-7 유방암 세포주의 성장억제 유도에 관한 연구
한국지역사회생활과학회지
2018 .11
-
Antioxidant Activity of Novel Casein- Derived Peptides with Microbial Proteases as Characterized via Keap1-Nrf2 Pathway in HepG2 Cells
Journal of Microbiology and Biotechnology
2021 .08
-
LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p
Genes & Genomics
2023 .05
-
Biological Functions and Identification of Novel Biomarker Expressed on the Surface of Breast Cancer-Derived Cancer Stem Cells via Proteomic Analysis
Molecules and Cells
2020 .01
-
Elucidating the Roles of the Casein Kinase 2 in the Pathogenicity of the Human Fungal Meningitis Pathogen Cryptococcus neoformans
한국미생물학회 학술대회논문집
2021 .08
-
한국 유방암 경험자들의 유방암 식사지침 수행 정도와 건강관련 삶의 질의 연관성
대한지역사회영양학회지
2015 .04
-
Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines
Animal cells and systems
2018 .01
-
Analysis of metabolites extracted from breast cancer cell lines using time-of-flight secondary ion mass spectrometry
한국진공학회 학술발표회초록집
2016 .08
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Oral Symptoms Related to Vitamin B12 Deficiency in a Patient with Crohn’s Disease
Joo-Hee Lee
,
Youn-Jung Pa
,
k
외 3명
Journal of Oral Medicine and Pain
2018
.12
Vitamin A and E Contents of Sauces, and Spices Consumed Nationwide in Korea
Hyun-Gyu Moon
,
Jiyeon Chun
한국식품영양과학회 학술대회발표집
2018
.10
Preparation and evaluation of vitamin C derivative based vesicles containing ascorbic acid
Jihea YANG
,
Hanyoung KIM
한국생물공학회 학술대회
2018
.10
The factors associated with Vitamin D deficiency in community dwelling elderly in Korea
Sun Hea Kim
,
Jung Eun Oh
,
Dong Won Song
외 8명
Nutrition Research and Practice
2018
.10
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-433-000151777