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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 553 - 561 (9page)
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초록· 키워드
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Pathogenic Acanthamoeba spp. cause granulomatous amoebic encephalitis and keratitis. Acanthamoeba keratitis (AK) is a rare but serious ocular infection that can result in permanent visual impairment or blindness. However, pathogenic factors of AK remain unclear and treatment for AK is arduous. Expression levels of proteins secreted into extracellular space were compared between A. castellanii pathogenic (ACP) and non-pathogenic strains. Two-dimensional polyacrylamide gel electrophoresis revealed 123 differentially expressed proteins, including 34 increased proteins , 7 qualitative increased proteins, 65 decreased proteins, and 17 qualitative decreased proteins in ACP strain. Twenty protein spots with greater than 5-fold increase in ACP strain were analyzed by liquid chromatography triple quadrupole mass spectrometry. These proteins showed similarity each to inosine-uridine preferring nucleoside hydrolase, carboxylesterase, oxygen-dependent choline dehydrogenase, periplasmic-binding protein proteinases and hypothetical proteins. These proteins expressed higher in ACP may provide some information to understand pathogenicity of Acanthamoeba.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Marciano-Cabral F / 2003 / Acanthamoeba spp. as agents of disease in humans / Clin Microbiol Rev 16 : 273 ~ 307
[학술지(정기간행물)] - Jones DB / 1975 / Acanthamoeba polyphaga keratitis and Acenthamoeba uveitis associated with fatal meningoencephalitis / Trans Ophthalmol Soc UK 95 : 221 ~ 232
[학술지(정기간행물)] - Verani JR / 2009 / National outbreak of Acanthamoeba keratitis associated with use of a contact lens solution, United States / Emerg Infect Dis 15 : 1236 ~ 1242
[학술지(정기간행물)] - Awwad ST / 2007 / Updates in Acanthamoeba keratitis / Eye Contact Lens 33 : 1 ~ 8
[학술지(정기간행물)] - Garate M / 2006 / In vitro pathogenicity of Acanthamoeba is associated with the expression of the mannose-binding protein / Invest Ophthalmol Vis Sci 47 : 1056 ~ 1062
[학술지(정기간행물)] - Jones DB / 1975 / Acanthamoeba polyphaga keratitis and Acenthamoeba uveitis associated with fatal meningoencephalitis / Trans Ophthalmol Soc UK 95 : 221 ~ 232
[학술지(정기간행물)] - Verani JR / 2009 / National outbreak of Acanthamoeba keratitis associated with use of a contact lens solution, United States / Emerg Infect Dis 15 : 1236 ~ 1242
[학술지(정기간행물)] - Awwad ST / 2007 / Updates in Acanthamoeba keratitis / Eye Contact Lens 33 : 1 ~ 8
[학술지(정기간행물)] - Garate M / 2006 / In vitro pathogenicity of Acanthamoeba is associated with the expression of the mannose-binding protein / Invest Ophthalmol Vis Sci 47 : 1056 ~ 1062
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UCI(KEPA) : I410-ECN-0101-2019-513-000329207