지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The hydroxylation of estradiol results in the formation of catechol estrogens such as 2-hydroxyestradiol (2-OHE₂) and 4-hydroxyestradiol (4-OHE₂). These catechol estrogens are further oxidized to quinone metabolites by peroxidases or cytochrome P450 (CYP450) enzymes. Catechol estrogens contribute to hormone-induced carcinogenesis by generating DNA adducts or reactive oxygen species (ROS). Interestingly, many of the natural products found in living organisms have been reported to show protective effects against carcinogenesis induced by catechol estrogens. Although some compounds have been reported to increase the activity of catechol estrogens via oxidation to quinone metabolites, many natural products decreased the activity of catechol estrogens by inhibiting DNA adduct formation, ROS production, or oxidative cell damage. Here we focus specifically on the chemopreventive effects of these natural compounds against carcinogenesis induced by catechol estrogens.
목차
INTRODUCTION
CONCLUSION
REFERENCES
참고문헌 (35)
참고문헌 신청
Borras C / 2006 / Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: Involvement of estrogen receptors, erk1/2, and nfkappab / FASEB J 20:2136~2138
Cavalieri E / 2006 / Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention / Biochim Biophys Acta 1766:63~78
Cavalieri EL / 1997 / Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators / Proc Natl Acad Sci USA 94:10937~10942
Chen ZH / 2004 / Resveratrol inhibits tcdd-induced expression of cyp1a1 and cyp1b1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells / Carcinogenesis 25:2005~2013
Dias DA / 2012 / A historical overview of natural products in drug discovery / Metabolites 2:303~336
Cavalieri E / 2006 / Catechol estrogen quinones as initiators of breast and other human cancers: Implications for biomarkers of susceptibility and cancer prevention / Biochim Biophys Acta 1766:63~78
Cavalieri EL / 1997 / Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators / Proc Natl Acad Sci USA 94:10937~10942
Chen ZH / 2004 / Resveratrol inhibits tcdd-induced expression of cyp1a1 and cyp1b1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells / Carcinogenesis 25:2005~2013
Dias DA / 2012 / A historical overview of natural products in drug discovery / Metabolites 2:303~336
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UCI(KEPA) : I410-ECN-0101-2019-510-000546492