지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 890 - 895 (6page)
이용수
초록· 키워드
오류제보하기
Since its discovery in 1989, hepatitis C virus (HCV) has been intensively investigated to understand its biology and develop effective antiviral therapies. The efforts of the previous 25 years have resulted in a better understanding of the virus, and this was facilitated by the development of in vitro cell culture systems for HCV replication. Antiviral treatments and sustained virological responses have also improved from the early interferon monotherapy to the current all-oral regimens using direct-acting antivirals. However, antiviral resistance has become a critical issue in the treatment of chronic hepatitis C, similar to other chronic viral infections, and retreatment options following treatment failure have become important questions. Despite the clinical challenges in the management of chronic hepatitis C, substantial progress has been made in understanding HCV, which may facilitate the investigation of other closely related flaviviruses and lead to the development of antiviral agents against these human pathogens.
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등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Alter HJ / 1975 / Clinical and serological analysis of transfusionassociated hepatitis / Lancet 2:838~841
Feinstone SM / 1975 / Transfusion-associated hepatitis not due to viral hepatitis type A or B / N Engl J Med 292:767~770
Choo QL / 1989 / Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome / Science 244:359~362
Lohmann V / 1999 / Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line / Science 285:110~113
Wakita T / 2005 / Production of infectious hepatitis C virus in tissue culture from a cloned viral genome / Nat Med 11:791~796
Feinstone SM / 1975 / Transfusion-associated hepatitis not due to viral hepatitis type A or B / N Engl J Med 292:767~770
Choo QL / 1989 / Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome / Science 244:359~362
Lohmann V / 1999 / Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line / Science 285:110~113
Wakita T / 2005 / Production of infectious hepatitis C virus in tissue culture from a cloned viral genome / Nat Med 11:791~796
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