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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 187 - 197 (11page)
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초록· 키워드
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This study has attempted to figure out the anti-oxidative effects of Machilusthunbergii extract through the scavenging of free radial and SOD activation andinvestigate its inhibiting effect on melanin production using B16 melanoma cells. Then,the following results were obtained: First, Cell viability was 100%, 99%, and 94% in 1,10, and 100 ㎍/㎖ of Machilus thunbergii extract. Second, according to measurement offree radical scavenging activities using DPPH solution, they were 9%, 55%, and 76% in 1,10, and 100 ㎍/㎖ of Machilus thunbergii extract. Third, in terms of SOD activities, theywere 4%, 54%, and 73% in 1, 10, and 100 ㎍/㎖ of Machilus thunbergii extract. Fourth,in terms of tyrosinase activities, they were inhibited by 15% and 24% in 10 and 100 ㎍/㎖ of Machilus thunbergii extract. Fifth, according to an analysis of its effects onmelanin production, the production was inhibited by 35% and 43% in 10 and 100 ㎍/㎖ ofMachilus thunbergii extract. Since Machilus thunbergii extract contains a lot offlavonoids, anti-oxidation and strong SOD activities were found. In addition, it hasinhibited melanin production by slowing down tyrosinase activities. Therefore, it appearsthat Machilus thunbergii extract would be available as an anti-oxidative or whiteningingredient in the cosmetics industry.
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참고문헌 (21)
참고문헌 신청
Gates, M.A. / 2007 / A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer / Int. J. cancer 121 (10) : 2225 ~ 2232
J. Pawelek / 1978 / Melanoma cells in culture / Methods Enzymol 58 : 564 ~
Jimenez M? / 1988 / Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone / Pro Natl Acad Sci USA 85 : 3830 ~ 3834
Kubo, I. / 2000 / Flavonols from Heterotheca inuloides. Tyrosinase inhibitory activity and structural criteria / Bioorg. Med. Chem 8 : 1749 ~ 1755
Kuwata, T. / 1993 / Proliferative activity of primary cutaneous melanocytic tumors / Virchows Archiv 423 (5) : 359 ~ 367
J. Pawelek / 1978 / Melanoma cells in culture / Methods Enzymol 58 : 564 ~
Jimenez M? / 1988 / Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone / Pro Natl Acad Sci USA 85 : 3830 ~ 3834
Kubo, I. / 2000 / Flavonols from Heterotheca inuloides. Tyrosinase inhibitory activity and structural criteria / Bioorg. Med. Chem 8 : 1749 ~ 1755
Kuwata, T. / 1993 / Proliferative activity of primary cutaneous melanocytic tumors / Virchows Archiv 423 (5) : 359 ~ 367
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