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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 65 - 72 (8page)
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Mitochondria are considered the power house of the cell and are an essential part of the cellular infrastructure, serving as the primary site for adenosine triphosphate production via oxidative phosphorylation. These organelles also release reactive oxygen species (ROS), which are normal byproducts of metabolism at physiological levels; however, overproduction of ROS under pathophysiological conditions is considered part of a disease process, as in sepsis. The inflammatory response inherent in sepsis initiates changes in normal mitochondrial functions that may result in organ damage. There is a complex system of interacting antioxidant defenses that normally function to combat oxidative stress and prevent damage to the mitochondria. It is widely accepted that oxidative stress-mediated injury plays an important role in the development of organ failure; however, conclusive evidence of any beneficial effect of systemic antioxidant supplementation in patients with sepsis and organ dysfunction is lacking. Nevertheless, it has been suggested that antioxidant therapy delivered specifically to the mitochondria may be useful.
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참고문헌 (51)
참고문헌 신청
Vincent JL / 2006 / Sepsis in European intensive care units: results of the SOAP study / Crit Care Med 34:344~353
Angus DC / 2001 / Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care / Crit Care Med 29:1303~1310
De Kock I / 2010 / Sepsis and septic shock: pathophysiological and cardiovascular background as basis for therapy / Acta Clin Belg 65:323~329
Mantzarlis K / 2017 / Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies / Oxid Med Cell Longev 2017:5985209
Fang X / 2018 / Role of mitochondrial dysfunction in the pathogenesis of septic cardiomyopathy / Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 30:189~192
Angus DC / 2001 / Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care / Crit Care Med 29:1303~1310
De Kock I / 2010 / Sepsis and septic shock: pathophysiological and cardiovascular background as basis for therapy / Acta Clin Belg 65:323~329
Mantzarlis K / 2017 / Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies / Oxid Med Cell Longev 2017:5985209
Fang X / 2018 / Role of mitochondrial dysfunction in the pathogenesis of septic cardiomyopathy / Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 30:189~192
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