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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제1호
- 발행연도
- 2004.1
- 수록면
- 1 - 7 (7page)
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초록· 키워드
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Background : Ginsenosides, the extract of Panax ginseng, exert various pharmacological
effects such as anticancer activity by the mechanism that is not yet defined. In this study, we
proposed that the anticancer effect of ginsenoside Rb1 is related to tumor cell apoptosis and
ginsenoside Rb1 induces the tumor cell apoptosis via the nitric oxide (NO) production. Methods
: Rat C6 glioma cells were activated by treating with lipopolysaccharide (LPS), interferon
(IFN)- , and tumor necrosis factor (TNF)- on the culture medium to investigate the effects
of ginsenoside Rb1. Results : Compared with C6 glioma cells treated with LPS/IFN- /TNF- ,
C6 glioma cells treated with LPS/IFN- /TNF- /ginsenoside Rb1 showed marked increase in
the NO production and apoptosis. Ginsenoside Rb1 induces the NO production in C6 glioma
cells in dose-dependent manner. When C6 glioma cells treated with LPS/IFN- /TNF- /ginsenoside
Rb1 were incubated with the specific inhibitor of iNOS, S-Methyl-2-thiopseudoureasulfate
(SMT), both NO production and apoptosis in C6 glioma cells was significantly decreased.
Ginsenoside Rb1 induced the expression of iNOS mRNA and iNOS protein in C6 glioma cells.
Conclusions : These results suggest that the induction of iNOS expression and subsequent
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참고문헌 (27)
참고문헌 신청
/ 1985 / influenceon neurotransmitter uptake in rat brain synaptosomes 3 : 221 ~ 4
/ 1987 / Plant-glycoside modulationof cell surface related to control of differentiation in culturedB16 melanoma cells 47 : 3863 ~ 7
/ 1993 / Inhibitoryeffects by oral administration of ginsenoside Rh2 on the growth ofhuman ovarian cancer cells in nude mice 120 : 24 ~ 6
/ 1995 / Inhibitory effect of tumormetastasis in mice by saponins,ginsenoside-Rb2 20(R)-and 20(S)-ginsenoside-Rg3, of red ginseng 18 : 1197 ~ 202
/ 1995 / Trial of a new medium-term model usingbenzo pyrene induced lung tumor in newborn mice 15 : 839 ~ 45
/ 1987 / Plant-glycoside modulationof cell surface related to control of differentiation in culturedB16 melanoma cells 47 : 3863 ~ 7
/ 1993 / Inhibitoryeffects by oral administration of ginsenoside Rh2 on the growth ofhuman ovarian cancer cells in nude mice 120 : 24 ~ 6
/ 1995 / Inhibitory effect of tumormetastasis in mice by saponins,ginsenoside-Rb2 20(R)-and 20(S)-ginsenoside-Rg3, of red ginseng 18 : 1197 ~ 202
/ 1995 / Trial of a new medium-term model usingbenzo pyrene induced lung tumor in newborn mice 15 : 839 ~ 45
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