지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제2호
- 발행연도
- 2015.1
- 수록면
- 95 - 98 (4page)
이용수
초록· 키워드
오류제보하기
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases, with a prevalence of up to 15%–20% in children and 2%–10% in adults. Patients with AD have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Recently, there has been increasing awareness of the importance of vitamin D, a potential factor, in the development and progression of atopic diseases including AD. Furthermore, some reports suggested that vitamin D deficiency impairs epithelial integrity, leading to increased and inappropriate mucosal exposure to antigens promoting sensitization. Even though numerous studies favor strong associations of vitamin D deficiency during pregnancy and infancy with allergies, high vitamin D intake might be harmful according to conflicting results of other trials. The growing body of the literature indicates an inverse relationship between the severity of AD and vitamin D levels. Animal studies, case reports, randomized clinical trials, and birth cohort studies have suggested that vitamin D may alleviate the symptoms of AD through immune-modulation of the innate and adaptive immune system. Moreover, some studies have shown that in individuals with AD with low vitamin D level, repletion of vitamin D results in decreased severity of diseases. However, all these results have prompted the question of which time, dose, duration, or mode of application of vitamin D might be appropriate in children with AD. Further large cohort studies and clinical trials are warranted to assess the role of vitamin D in the prevention and treatment of AD in children.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Amestejani M / 2012 / Vitamin D supplementation in the treatment of atopic dermatitis : a clinical trial study / J Drugs Dermatol 11 : 327 ~ 330
Baek JH / 2014 / The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy / J Pediatr 165 : 849 ~ 854.el
Baiz N / 2014 / Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis / J Allergy Clin Immunol 133 : 147 ~ 153
Benson AA / 2012 / The role of vitamin D in the immunopathogenesis of allergic skin diseases / Allergy 67 : 296 ~ 301
Buchau AS / 2009 / Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes / J Invest Dermatol 129 : 2148 ~ 2155
Baek JH / 2014 / The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy / J Pediatr 165 : 849 ~ 854.el
Baiz N / 2014 / Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis / J Allergy Clin Immunol 133 : 147 ~ 153
Benson AA / 2012 / The role of vitamin D in the immunopathogenesis of allergic skin diseases / Allergy 67 : 296 ~ 301
Buchau AS / 2009 / Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes / J Invest Dermatol 129 : 2148 ~ 2155
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