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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 644 - 651 (8page)
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초록· 키워드
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ObjectiveaaCytokines have been reported to have key roles in major depressive disorder (MDD). However, much less is known about cytokines in MDD and antidepressant treatment due to the diversity of cytokines and the heterogeneity of depression. We investigated the levels of cytokines in patients with MDD compared with healthy subjects and their associations with antidepressant response.
MethodsaaWe investigated the changes of several cytokines (eotaxin, sCD40L, IL-8, MCP-1alpha, TNF-alpha, INF-gamma and MIP-1alpha) by Luminex assay in 66 patients with MDD and 22 healthy controls. The antidepressant response was assessed by 17-item Hamilton Rating Scale for Depression.
ResultsaaWe found the levels of sCD40L (p=0.001), IL-8 (p=0.004) and MCP-1 (p=0.03) of healthy controls were significantly higher than those of depressive patients. However, the level of eotaxin and TNF-alpha were not associated with MDD. In addition, we found the level of MCP-1 was significantly changed after antidepressant treatment (p=0.01).
ConclusionaaThese findings suggest the roles of cytokines in MDD are complex, and could vary according to the individual characteristics of each patient. Further studies regarding the relationship between cytokines and MDD will be required.
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등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Kessler RC / 2005 / Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication / Arch Gen Psychiatry 62:617~627
Capuron L / 2011 / Immune system to brain signaling : neuropsychopharmacological implications / Pharmacol Ther 130:226~238
Leonard BE / 2010 / The concept of depression as a dysfunction of the immune system / Curr Immunol Rev 6:205~212
Leonard BE / 1996 / Stress and the immune system in the etiology of anxiety and depression / Pharmacol Biochem Behav 54:299~303
Miller AH / 1998 / Neuroendocrine and immune system interactions in stress and depression / Psychiatr Clin North Am 21:443~463
Capuron L / 2011 / Immune system to brain signaling : neuropsychopharmacological implications / Pharmacol Ther 130:226~238
Leonard BE / 2010 / The concept of depression as a dysfunction of the immune system / Curr Immunol Rev 6:205~212
Leonard BE / 1996 / Stress and the immune system in the etiology of anxiety and depression / Pharmacol Biochem Behav 54:299~303
Miller AH / 1998 / Neuroendocrine and immune system interactions in stress and depression / Psychiatr Clin North Am 21:443~463
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