지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 46 - 54 (9page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaSecond-generation antipsychotics have been repeatedly shown to be superior to placebo. However, the comparative efficacy among these drugs has not been systematically evaluated. In this study, we used Mixed Treatment Comparison (MTC) procedures to elucidate the comparative efficacy and tolerability of second-generation antipsychotics.
MethodsaaSeven antipsychotics were selected based on the availability of the relevant data. Data were gathered from a series of review article published by the Cochrane Collaboration. Six outcome measures were analyzed: 1) percentage of no clinically important response as defined by the original authors, 2) PANSS total score change from baseline to endpoint, 3) percentage of akathisia, 4) percentage of antiparkinson medication use, 5) percentage of total body weight increase more than 7%, and 6) percentage of drop-out due to any reasons.
ResultsaaAll the second-generation antipsychotics included in this study showed fairly similar efficacy but widely different tolerability. In terms of efficacy, amisulpride, clozapine and olanzapine were ranked higher than aripiprazole, quetiapine and ziprasidone. Clozapine and olanzapine were superior in terms of akathisia and extrapyramidal symptom risk, but, far more prone to induce clinically important weight gain.
ConclusionaaUsing MTC methodology, we could line up the second generation antipsychotics according to their hierarchical superiority in terms of efficacy and tolerability. Though the wide overlap among the confidence intervals and the inconsistency between the direct and indirect comparison results may limit the validity of these results, it may still allow the important insights into the relative merits of the available drugs.
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Khanna P / 2013 / Aripiprazole versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev 2:CD006569
Komossa K / 2010 / Amisulpride versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev :CD006624
Komossa K / 2010 / Quetiapine versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev :CD006625
Komossa K / 2010 / Olanzapine versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev :CD006654
Komossa K / 2009 / Aripiprazole versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev :CD006569
Komossa K / 2010 / Amisulpride versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev :CD006624
Komossa K / 2010 / Quetiapine versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev :CD006625
Komossa K / 2010 / Olanzapine versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev :CD006654
Komossa K / 2009 / Aripiprazole versus other atypical antipsychotics for schizophrenia / Cochrane Database Syst Rev :CD006569
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
조현병 환자에서 항정신병약물 유지치료 시 치료결과에 대한 연구
대한조현병학회지
2017 .10
-
Understanding of Antipsychotics in Elderly Patients with Dementia
Dementia and Neurocognitive Disorders(대한치매학회지)
2015 .01
-
Antipsychotic Prescribing Patterns in First-episode Schizophrenia: A Five-year Comparison
Clinical Psychopharmacology and Neuroscience
2015 .01
-
양극성장애에서 Antipsychotics의 사용 전략
신경정신의학
2018 .01
-
‘2019 한국형 조현병 약물치료 지침서’에 따른 조현병에서 동반증상 및 부작용의 치료
대한조현병학회지
2019 .01
-
Clinical Usefulness of Amisulpride Add-on Therapy in Schizophrenia Patients without Treatment Response to Second-generation Antipsychotics
Clinical Psychopharmacology and Neuroscience
2021 .01
-
항정신병약물의 생물학적 기전 최신 지견
신경정신의학
2019 .01
-
Exploring Hidden Issues in the Use of Antipsychotic Polypharmacy in the Treatment of Schizophrenia
Clinical Psychopharmacology and Neuroscience
2021 .11
-
항정신병 약물의 병용요법을 사용 중인 환자들에서 아리피프라졸 장기 지속형 주사제의 효능
생물치료정신의학
2024 .10
-
항정신병약물에 의한 대사부작용에 대한 이론과 대처방안
신경정신의학
2019 .01
-
Diabetic Ketoacidosis Associated With Second Generation Antipsychotics: A Case Study and Review of Literature
PSYCHIATRY INVESTIGATION
2024 .02
-
조현병 약물치료의 최신 지견
대한의사협회지
2024 .02
-
Quantitative Resting State Electroencephalography in Patients with Schizophrenia Spectrum Disorders Treated with Strict Monotherapy Using Atypical Antipsychotics
Clinical Psychopharmacology and Neuroscience
2021 .01
-
Target Discovery Using Deep Learning-Based Molecular Docking and Predicted Protein Structures With AlphaFold for Novel Antipsychotics
PSYCHIATRY INVESTIGATION
2023 .06
-
항정신병약물 임상의 역사와 미래
신경정신의학
2019 .01
-
Clinical Characteristics of Patients with Schizophrenia Maintained without Antipsychotics: A Cross-sectional Survey of a Case Series
Clinical Psychopharmacology and Neuroscience
2021 .11
-
Assessment of the Latent Adverse Events of Antipsychotic Treatment Using a Subjective Questionnaire in Japanese Patients with Schizophrenia
Clinical Psychopharmacology and Neuroscience
2017 .01
-
Evaluation of Paraoxonase, Arylesterase and Malondialdehyde Levels in Schizophrenia Patients Taking Typical, Atypical and Combined Antipsychotic Treatment
Clinical Psychopharmacology and Neuroscience
2016 .01
-
항정신병 약물 사용 및 치매의 심리행동 증상과 알츠하이머 환자의 인지능력 저하와의 연관성
노인정신의학
2021 .10
-
Antipsychotic Medication in Schizophrenic Patients is Associated with Higher Risks of Developing Bone Fractures and Refractures
Clinical Psychopharmacology and Neuroscience
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0