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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 251 - 258 (8page)
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Purpose In this study, we retrospectively investigated the prevalence of arterioportal (AP) shunts inhepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) andevaluated the changes in AP shunts after chemoembolization followed by external beamradiation therapy (EBRT).
Materials and MethodsWe analyzed 54 HCC patients with PVTT who were treated with chemoembolization followedby EBRT. EBRT was uniformly delivered at a total dose of 30 to 45 Gy (median, 35 Gy), witha daily dose of 2 to 4.5 Gy. Angiographic images of chemoembolization before and afterradiation therapy (RT) were reviewed to investigate the AP shunt.
ResultsDuring the initial session of chemoembolization, 33 of 54 patients (61%) had an AP shunt.
After EBRT, 32 out of 33 patients had an additional session of chemoembolization and wereevaluated for a change in the AP shunt. The AP shunt decreased in 20 of 32 patients (63%)after chemoembolization followed by EBRT. The 1-year calculated overall survival (OS) ratefor all patients was 52.6% and the 2-year OS was 36.4%. The median OS in all patients was13 months. Patients with AP shunt showed poorer median OS than those without AP shunt,but there was no statistically significant difference (median, 12 months vs. 17 months).
ConclusionThe AP shunt frequently occurs in HCC patients with PVTT. This study suggests that a poorprognosis is associated with an AP shunt. Chemoembolization followed by RT may producea decrease in AP shunts.
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참고문헌 (20)
참고문헌 신청
/ 2000 / Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. The Cancer of the Liver Italian Program (
/ 2012 / European Association for Study of Liver; European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocel
Bookstein JJ / 1982 / Arterioportal communications : observations and hypotheses concerning transsinusoidal and transvasal types / Radiology 142 : 581 ~ 590
Breen DJ / 2004 / Intrahepatic arterioportal shunting and anomalous venous drainage : understanding the CT features in the liver / Eur Radiol 14 : 2249 ~ 2260
Davidson BR / 1994 / Incidence, risk factors, management, and outcome of portal vein abnormalities at orthotopic liver transplantation / Transplantation 57 : 1174 ~ 1177
/ 2012 / European Association for Study of Liver; European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocel
Bookstein JJ / 1982 / Arterioportal communications : observations and hypotheses concerning transsinusoidal and transvasal types / Radiology 142 : 581 ~ 590
Breen DJ / 2004 / Intrahepatic arterioportal shunting and anomalous venous drainage : understanding the CT features in the liver / Eur Radiol 14 : 2249 ~ 2260
Davidson BR / 1994 / Incidence, risk factors, management, and outcome of portal vein abnormalities at orthotopic liver transplantation / Transplantation 57 : 1174 ~ 1177
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