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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 29 - 36 (8page)
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Purpose Metformin is associated with an anticancer effect. However, the effects of metformin in rectal cancer are controversial. This study investigated the impact of metformin on the survival of patients with diabetes mellitus and nonmetastatic rectal cancer who underwent curative surgery.
Materials and Methods The database was provided by the Korea Center Cancer Registry and National Health Insurance Service of the Republic of Korea. A cohort of patients with newly diagnosed rectal cancer between 2005 and 2011 was identified. Drug exposure was defined as receiving the oral hypoglycemic agent for at least 90 days over the period from 6 months before the initial diagnosis of rectal cancer to the last follow-up.
Results A total of 4,503 patients were prescribed oral hypoglycemic agents and classified as the diabetic group, of which 3,694 patients received metformin for at least 90 days. Unadjusted analyses showed a significantly higher overall survival (hazard ratio, 0.596; 95% confidence interval, 0.506 to 0.702) and rectal cancer-specific survival (hazard ratio, 0.621; 95% confidence interval, 0.507 to 0.760) in the metformin group than in the nonmetformin group.
The adjusted overall survival (hazard ratio, 0.631; 95% confidence interval, 0.527 to 0.755) and cancer-specific survival (hazard ratio, 0.598; 95% confidence interval, 0.479 to 0.746) in the group with a medication possession ratio of 80% or greater was significantly higher than in the group with a medication possession ratio of less than 80%.
Conclusion Metformin use is associated with overall and cancer-specific survival in diabetic patients with a nonmetastatic rectal cancer treated with a curative resection.
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참고문헌 (25)
참고문헌 신청
Cardel M / 2014 / Long-term use of metformin and colorectal cancer risk in type II diabetics : a population-based case-control study / Cancer Med 3 : 1458 ~ 1466
Charlson ME / 1987 / A new method of classifying prognostic comorbidity in longitudinal studies : development and validation / J Chronic Dis 40 : 373 ~ 383
Chowdhury TA / 2010 / Diabetes and cancer / QJM 103 : 905 ~ 915
Cossor FI / 2013 / Diabetes, metformin use, and colorectal cancer survival in postmenopausal women / Cancer Epidemiol 37 : 742 ~ 749
Coughlin SS / 2004 / Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults / Am J Epidemiol 159 : 1160 ~ 1167
Charlson ME / 1987 / A new method of classifying prognostic comorbidity in longitudinal studies : development and validation / J Chronic Dis 40 : 373 ~ 383
Chowdhury TA / 2010 / Diabetes and cancer / QJM 103 : 905 ~ 915
Cossor FI / 2013 / Diabetes, metformin use, and colorectal cancer survival in postmenopausal women / Cancer Epidemiol 37 : 742 ~ 749
Coughlin SS / 2004 / Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults / Am J Epidemiol 159 : 1160 ~ 1167
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