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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,351 - 1,361 (11page)
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Purpose Molecular treatments targeting epidermal growth factor receptors (EGFRs) are important strategies for advanced colorectal cancer (CRC). However, clinicopathologic implications of EGFRs and EGFR ligand signaling have not been fully evaluated. We evaluated the expression of EGFR ligands and correlation with their receptors, clinicopathologic factors, and patients’ survival with CRC. Materials and Methods The expression of EGFR ligands, including heparin binding epidermal growth factor–like growth factor (HBEGF), transforming growth factor (TGF), betacellulin, and epidermal growth factor (EGF), were evaluated in 331 consecutive CRC samples using mRNA in situ hybridization (ISH). We also evaluated the expression status of EGFR, human epidermal growth factor receptor 2 (HER2), HER3, and HER4 using immunohistochemistry and/or silver ISH. Results Unlike low incidences of TGF (38.1%), betacellulin (7.9%), and EGF (2.1%), HBEGF expression was noted in 62.2% of CRC samples. However, the expression of each EGFR ligand did not reveal significant correlations with survival. The combined analyses of EGFR ligands and EGFR expression indicated that the ligands/EGFR+ group showed a significant association with the worst disease-free survival (DFS; p=0.018) and overall survival (OS; p=0.005). It was also an independent, unfavorable prognostic factor for DFS (p=0.026) and OS (p=0.007). Additionally, HER4 nuclear expression, regardless of ligand expression, was an independent, favorable prognostic factor for DFS (p=0.034) and OS (p=0.049), by multivariate analysis. Conclusion Ligand-independent EGFR overexpression was suggested to have a significant prognostic impact; thus, the expression status of EGFR ligands, in addition to EGFR, might be necessary for predicting patients' outcome in CRC.
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참고문헌 (29)
참고문헌 신청
Spano JP / 2005 / Impact of EGFR expression on colorectal cancer patient prognosis and survival / Ann Oncol 16:102~108
Nagahiro Saijo / 2012 / Present Status and Problems on Molecular Targeted Therapy of Cancer / Cancer Research and Treatment 44(1):1~10
김달용 / 2017 / Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer / Cancer Research and Treatment 49(1):37~43
Karapetis CS / 2008 / K-ras mutations and benefit from cetuximab in advanced colorectal cancer / N Engl J Med 359:1757~1765
Schneider MR / 2009 / The epidermal growth factor receptor ligands at a glance / J Cell Physiol 218:460~466
Nagahiro Saijo / 2012 / Present Status and Problems on Molecular Targeted Therapy of Cancer / Cancer Research and Treatment 44(1):1~10
김달용 / 2017 / Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer / Cancer Research and Treatment 49(1):37~43
Karapetis CS / 2008 / K-ras mutations and benefit from cetuximab in advanced colorectal cancer / N Engl J Med 359:1757~1765
Schneider MR / 2009 / The epidermal growth factor receptor ligands at a glance / J Cell Physiol 218:460~466
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