본문 바로가기
[학술저널]

  • 학술저널

김희정 장자현 유은형 김희진 기창석 김종원 김선희

발행기관의 요청으로 개인이 구매하실 수 없습니다.

표지

북마크 0

리뷰 0

이용수 0

피인용수 0

초록

JAK2 V617F and MPL W515L/K mutations have been reported in approximately 50% and 5% of the patients with essential thrombocythemia (ET), respectively. We investigated the frequency of MPL W515L/K mutations in a series of consecutive patients with ET and post-essential thrombocythemia myelofibrosis (post-ET MF). The study subjects were 63 patients diagnosed either with ET (N=59) or post-ET MF (N=4) at our institution between June 2006 and February 2010. Among them, 35 (55.6%) had the JAK2 V617F mutation. MPL W515L/K mutations were detected by direct sequencing analyses of exon 10, and 2 patients were found to harbor the following MPL mutations: W515L in 1 patient with ET and W515K in 1 patient with post-ET MF. Neither of the patients had the JAK2 V617F mutation. The frequencies of the MPL W515L/K and JAK2 V617F-negative mutations in our subjects with ET/post-ET MF were 3.2% (2/63) and 7.1% (2/28), respectively. This is the first study to report the frequency of JAK2 V617F and MPL W515L/K mutations in Korean patients with ET/post-ET MF. (Korean J Lab Med 2010;30:474-6)

목차

등록된 정보가 없습니다.

리뷰(0)

도움이 되었어요.0

도움이 안되었어요.0

첫 리뷰를 남겨주세요.
DBpia에서 서비스 중인 논문에 한하여 피인용 수가 반영됩니다.
인용된 논문이 DBpia에서 서비스 중이라면, 아래 [참고문헌 신청]을 통해서 등록해보세요.
Insert title here