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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 44 - 54 (11page)
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초록· 키워드
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Abstract
Objectives The purpose of this study was to evaluate the histopathological effects of an antioxidant therapy on the pulp tissue of rat teeth exposed to a bleaching gel with 35% hydrogen peroxide.
Materials and Methods Forty rats were subjected to oral ingestion by gavage of distilled water (DW) or ascorbic acid (AA) 90 min before the bleaching therapy. For the bleaching treatment, the agent was applied twice for 5 min each to buccal surfaces of the first right mandibular molars. Then, the animals were sacrificed at 6 hr, 24 hr, 3 day, or 7 day post-bleaching, and the teeth were processed for microscopic evaluation of the pulp tissue.
Results At 6 hr, the pulp tissue showed moderate inflammatory reactions in all teeth of both groups. In the DW and AA groups, 100% and 80% of teeth exhibited pulp tissue with significant necrosis and intense tissue disorganization, respectively. At 24 hr, the AA-treated group demonstrated a greater regenerative capability than the DW group, with less intense inflammatory reaction and new odontoblast layer formation in 60% of the teeth. For up to the 7 day period, the areas of pulpal necrosis were replaced by viable connective tissue, and the dentin was underlined by differentiated odontoblast-like cells in most teeth of both groups.
Conclusions A slight reduction in initial pulpal damage during post-bleaching was promoted by AA therapy. However, the pulp tissue of AA-treated animals featured faster regenerative potential over time.
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참고문헌 (37)
참고문헌 신청
Cintra LT / 2013 / The number of bleaching sessions influences pulp tissue damage in rat teeth / J Endod 39:1576~1580
Soares DG / 2014 / Concentrations of and application protocols for hydrogen peroxide bleaching gels: effects on pulp cell viability and whitening efficacy / J Dent 42:185~198
Soares DG / 2015 / Effect of hydrogen-peroxide-mediated oxidative stress on human dental pulp cells / J Dent 43:750~756
Soares DG / 2016 / Indirect cytocompatibility of a low-concentration hydrogen peroxide bleaching gel to odontoblast-like cells / Int Endod J 49:26~36
de Almeida LC / 2012 / Occurrence of sensitivity during at-home and in-office tooth bleaching therapies with or without use of light sources / Acta Odontol Latinoam 25:3~8
Soares DG / 2014 / Concentrations of and application protocols for hydrogen peroxide bleaching gels: effects on pulp cell viability and whitening efficacy / J Dent 42:185~198
Soares DG / 2015 / Effect of hydrogen-peroxide-mediated oxidative stress on human dental pulp cells / J Dent 43:750~756
Soares DG / 2016 / Indirect cytocompatibility of a low-concentration hydrogen peroxide bleaching gel to odontoblast-like cells / Int Endod J 49:26~36
de Almeida LC / 2012 / Occurrence of sensitivity during at-home and in-office tooth bleaching therapies with or without use of light sources / Acta Odontol Latinoam 25:3~8
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