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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제3호
- 발행연도
- 2015.1
- 수록면
- 283 - 287 (5page)
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초록· 키워드
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Objective: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is widely expressed in the mammalian brain and acts to regulate neuronal survival and influence cognitive processes. The present study measured serum BDNF levels to investigate the associations of the BDNF Val66Met and 5-hydroxytryptamine transporter linked promoter region (5-HTTLPR) polymorphisms with cognitive function in elderly Korean individuals.
Methods: Over 60 years, a total of 834 subjects were recruited for the present study. The subjects were classified into groups based on the degree of cognitive impairment (age-associated cognitive decline, mild cognitive impairment, and Alzheimer’s disease) and compared with normal controls in terms of a neuropsychological assessment and a clinical evaluation.
Results: Of the initial 834 study participants, 165 (59 controls and 106 subjects with cognitive impairments) completed the study.
There was a significant increase in serum BDNF levels in subjects with cognitive impairments relative to the control group and the BDNF Val66Met polymorphism was significantly associated with cognitive function but not serum BDNF levels. The 5-HTTLPR polymorphism did not have any associations with cognitive impairment or serum BDNF levels.
Conclusion: The present findings suggest that BDNF may play a role in the pathophysiology of cognitive impairment and the BDNF Val66Met polymorphism may be an important factor in the susceptibility to these age-related deficits.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Angelucci F. / 2010 / Alzheimer's disease(AD)and Mild Cognitive Impairment(MCI)patients are characterized by increased BDNF serum levels / Curr Alzheimer Res 7 : 15 ~ 20
Bagnoli S. / 2004 / Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy / Ann Neurol 55 : 447 ~ 448
Borroni B. / 2006 / Cumulative effect of COMT and 5-HTTLPR polymorphisms and their interaction with disease severity and comorbidities on the risk of psychosis in Alzheimer
Bramham CR. / 2005 / BDNF function in adult synaptic plasticity : the synaptic consolidation hypothesis / Prog Neurobiol 76 : 99 ~ 125
Combarros O. / 2004 / Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease / Dement Geriatr Cogn Disord
Bagnoli S. / 2004 / Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy / Ann Neurol 55 : 447 ~ 448
Borroni B. / 2006 / Cumulative effect of COMT and 5-HTTLPR polymorphisms and their interaction with disease severity and comorbidities on the risk of psychosis in Alzheimer
Bramham CR. / 2005 / BDNF function in adult synaptic plasticity : the synaptic consolidation hypothesis / Prog Neurobiol 76 : 99 ~ 125
Combarros O. / 2004 / Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease / Dement Geriatr Cogn Disord
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