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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제3호
- 발행연도
- 2015.1
- 수록면
- 227 - 238 (12page)
이용수
초록· 키워드
오류제보하기
The dopamine transporter is responsible for recycling dopamine after release. Inhibitors of the dopamine transporter, such as cocaine, will stop the reuptake of dopamine and allow it to stay extracellularly, causing prominent changes at the molecular, cellular, and behavioral levels. There is much left to be known about the mechanism and site(s) of binding, as well as the effect that cocaine administration does to dopamine transporter-cocaine binding sites and gene expression which also plays a strong role in cocaine abusers and their behavioral characteristics. Thus, if more light is shed on the dopamine transporter-cocaine interaction, treatments for addiction and even other diseases of the dopaminergic system may not be too far ahead. As today’s ongoing research expands on the shoulders of classic research done in the 1990s and 2000s, the foundation of core research done in that time period will be reviewed, which forms the basis of today’s work and tomorrow’s therapies.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Barr GA. / 1992 / Conditioned place preference from ventral tegmental injection of morphine in neonatal rats / Brain Res Dev Brain Res 66 : 133 ~ 136
Beuming T. / 2008 / The binding sites for cocaine and dopamine in the dop
Buck KJ. / 1994 / Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium / Pro
Buck KJ. / 1995 / Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants / Mol Pharmacol 48
Childress AR. / 1999 / Limbic activation during cueinduced cocaine craving / Am J Psychiatry 156 : 11 ~ 18
Beuming T. / 2008 / The binding sites for cocaine and dopamine in the dop
Buck KJ. / 1994 / Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium / Pro
Buck KJ. / 1995 / Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants / Mol Pharmacol 48
Childress AR. / 1999 / Limbic activation during cueinduced cocaine craving / Am J Psychiatry 156 : 11 ~ 18
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