지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제45권 제1호
- 발행연도
- 2015.1
- 수록면
- 14 - 22 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: The purpose of this study was to compare serum amyloid A (SAA) protein levelswith high-sensitive C-reactive protein (hs-CRP) levels as markers of systemic inflammationin patients with chronic periodontitis. The association of serum titers of antibodies to periodontalmicrobiota and SAA/hs-CRP levels in periodontitis patients was also studied.
Methods: A total of 110 individuals were included in this study. Patients were assessed forlevels of hs-CRP and SAA. Nonfasting blood samples were collected from participants atthe time of clinical examination. The diagnosis of adipose tissue disorders was made accordingto previously defined criteria. To determine SAA levels, a sandwich enzyme-linkedimmunosorbent assay was utilized. Paper points were transferred to a sterile tube to obtaina pool of samples for polymerase chain reaction processing and the identification of Porphyromonasgingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia.
The serum level of IgG1 and IgG2 antibodies to P. gingivalis, A. actinomycetemcomitans,and T. forsythia was also determined.
Results: SAA and hs-CRP levels were higher in periodontitis patients than in controls(P<0.05). In bivariate analysis, high levels of hs-CRP (>3 mg/L) and SAA (>10 mg/L) weresignificantly associated with chronic periodontitis (P=0.004). The Spearman correlationanalysis between acute-phase proteins showed that SAA positively correlated with hs-CRP(r=0.218, P=0.02). In the adjusted model, chronic periodontitis was associated with highlevels of SAA (odds ratio [OR], 5.5; 95% confidence interval [CI], 1.6–18.2; P=0.005) andelevated hs-CRP levels (OR, 6.1, 95% CI, 1.6–23.6; P=0.008). Increased levels of serum IgG2antibodies to P. gingivalis were associated with high levels of SAA (OR, 3.6; 95% CI, 1.4–8.5;P=0.005) and high concentrations of hs-CRP (OR, 4.3; 95% CI, 1.9–9.8; P<0.001).
Conclusions: SAA and hs-CRP concentrations in patients with chronic periodontitis arecomparably elevated. High serum titers of antibodies to P. gingivalis and the presence ofperiodontal disease are independently related to high SAA and hs-CRP levels.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Aoki-Nonaka Y / 2014 / Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas
Ashimoto A / 1996 / Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions / Oral Mic
Bishop RF / 1984 / Estimation of rotavirus immunoglobulin G antibodies in human serum samples by enzyme-linked immunosorbent assay: expression of results as units derived fr
Chait A / 2005 / Thematic review series:the immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease? / J
Cunnane G / 2000 / Serum amyloid A in the assessment of early inflammatory arthritis / J Rheumatol 27 : 58 ~ 63
Ashimoto A / 1996 / Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions / Oral Mic
Bishop RF / 1984 / Estimation of rotavirus immunoglobulin G antibodies in human serum samples by enzyme-linked immunosorbent assay: expression of results as units derived fr
Chait A / 2005 / Thematic review series:the immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease? / J
Cunnane G / 2000 / Serum amyloid A in the assessment of early inflammatory arthritis / J Rheumatol 27 : 58 ~ 63
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pretreatment Serum Amyloid A and C-reactive Protein Comparing with Epstein-Barr Virus DNA as Prognostic Indicators in Patients with Nasopharyngeal Carcinoma: A Prospective Study
Cancer Research and Treatment
2018 .01
-
Regulation of serum amyloid A (SAA) and its association with SAA1-derived amyloid deposition in a hepatic SAA1-overexpression mouse
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Amyloid beta plaque accumulation and memory function decline exacerbated by SAA1 in Alzheimer’s disease
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Serum Amyloid A1: A Biomarker for Neutrophilic Airway Inflammation in Adult Asthmatic Patients
Allergy, Asthma & Immunology Research
2022 .01
-
Higher Serum C Reactive Protein Determined C Reactive Protein Single-Nucleotide Polymorphisms Are Involved in Inherited Depression
PSYCHIATRY INVESTIGATION
2018 .01
-
Regulation of serum amyloid A1 (SAA1) levels and amyloid deposition in a transgenic mouse model challenged with a high‐fat diet and overexpressing hepatic SAA1
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Avidity of serum immunoglobulin G antibodies to Porphyromonas gingivalis in the elderly with chronic periodontitis
International Journal of Oral Biology
2019 .01
-
Serum amyloid A1 aggravates Alzheimer’s disease through amyloid beta plaque accumulation and memory function decline
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Serum amyloid A1 (SAA1) levels and amyloid deposition following high-fat diet challenge in transgenic mice overexpressing hepatic SAA1
한국실험동물학회 학술발표대회 논문집
2016 .02
-
40세 이상의 상대적 악력과 치주질환 관련성 연구 : 고감도 C-반응 단백의 매개효과를 중심으로
대한보건연구
2023 .02
-
C-reactive Protein Concentration Is Associated With a Higher Risk of Mortality in a Rural Korean Population
예방의학회지
2016 .01
-
한국 성인에서 우울증과 hs-CRP 혈중 농도와의 연관성: 국민건강영양조사 2018년 자료 이용
Korean Journal of Family Practice
2021 .01
-
증상 발현 후 6시간 이내 응급실 도착한 급성심근경색증에서 hs-CRP 및 CRP velocity와 재원 기간 내 단기 예후와의 상관 관계
대한응급의학회지
2021 .01
-
High-Sensitivity C-Reactive Protein Can Reflect Small Airway Obstruction in Childhood Asthma
Yonsei Medical Journal
2016 .01
-
The effect of shift work on high sensitivity C-reactive protein level among female workers
대한직업환경의학회지
2019 .05
-
Disease Phenotype, Activity and Clinical Course Prediction Based on C-Reactive Protein Levels at Diagnosis in Patients with Crohn’s Disease: Results from the CONNECT Study
Gut and Liver
2016 .01
-
급성 신우신염 환자의 중증도 예측에 CRP velocity의 유용성
대한응급의학회지
2015 .01
-
C-reactive Protein Overexpression in the Background Liver of Hepatitis B Virus–Associated Hepatocellular Carcinoma Is a Prognostic Biomarker
Journal of Pathology and Translational Medicine
2018 .01
-
Utilization of C-Reactive Protein Test as a Predictor of Lung Injury in Patients with Coronavirus Disease 2019
Laboratory Medicine Online
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0