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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치과보철학회 The Journal of Advanced of Prosthodontics The Journal of Advanced of Prosthodontics 제10권 제2호
- 발행연도
- 2018.1
- 수록면
- 147 - 154 (8page)
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초록· 키워드
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PURPOSE. This study was performed to evaluate the osteogenic potential of 3mol% yttria-stabilized tetragonal zirconia polycrystals (3Y-TZP) and niobium oxide containing Y-TZPs with specific ratios, new (Y,Nb)-TZPs, namely YN4533 and YN4533/Al20 discs. MATERIALS AND METHODS. 3Y-TZP, YN4533 and YN4533/Al20 discs (15 mm diameter and 1 mm thickness) were prepared and their average surface roughness (Ra) and surface topography were analyzed using 3-D confocal laser microscope (CLSM) and scanning electron microscope (SEM). Mouse pre-osteoblast MC3T3-E1 cells were seeded onto all zirconia discs and evaluated with regard to cell attachment and morphology by (CLSM), cell proliferation by PicoGreen assay, and cell differentiation by Reverse-Transcription PCR and Quantitative Real-Time PCR, and alkaline phosphatase (Alp) staining. RESULTS. The cellular morphology of MC3T3-E1 pre-osteoblasts was more stretched on a smooth surface than on a rough surface, regardless of the material. Cellular proliferation was higher on smooth surfaces, but there were no significant differences between 3Y-TZP, YN4533, and YN4533/Al20. Osteoblast differentiation patterns on YN4533 and YN4533/Al20 were similar to or slightly higher than seen in 3Y-TZP. Although there were no significant differences in bone marker gene expression (alkaline phosphatase and osteocalcin), Alp staining indicated better osteoblast differentiation on YN4533 and YN4533/Al20 compared to 3Y-TZP. CONCLUSION. Based on these results, niobium oxide containing Y-TZPs have comparable osteogenic potential to 3Y-TZP and are expected to be suitable alternative ceramics dental implant materials to titanium for aesthetically important areas.
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참고문헌 (47)
참고문헌 신청
Astrand P / 2008 / Implant treatment of patients with edentulous jaws: a 20-year follow-up / Clin Implant Dent Relat Res 10:207~217
Adell R / 1990 / Long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws / Int J Oral Maxillofac Implants 5:347~359
Steinemann SG / 1998 / Titanium-the material of choice? / Periodontol 2000 17:7~21
Depprich R / 2008 / Osseointegration of zirconia implants compared with titanium: an in vivo study / Head Face Med 4:30
Heydecke G / 1999 / Optimal esthetics in singletooth replacement with the Re-Implant system: a case report / Int J Prosthodont 12:184~189
Adell R / 1990 / Long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws / Int J Oral Maxillofac Implants 5:347~359
Steinemann SG / 1998 / Titanium-the material of choice? / Periodontol 2000 17:7~21
Depprich R / 2008 / Osseointegration of zirconia implants compared with titanium: an in vivo study / Head Face Med 4:30
Heydecke G / 1999 / Optimal esthetics in singletooth replacement with the Re-Implant system: a case report / Int J Prosthodont 12:184~189
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