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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
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- 1 - 7 (7page)
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One of the main compounds in Ishige okamurae, diphlorethohydroxycarmalol (DPHC), is known to exhibit antiviral and anti-inflammatory effects. However, it has not been investigated extensively. In this study, preparative centrifugal partition chromatography (CPC) coupled with 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+) online HPLC was employed for effectively separating considerable amounts of antioxidant compounds from marine algae. Two main antioxidant compounds, DPHC and octaphlorethol A (OPA), respectively, were confirmed and isolated from the ethyl acetate (EtOAc) fraction of I. okamurae by ABTS+ online HPLC and preparative CPC systems. The presence of DPHC and OPA was confirmed in the EtOAc fraction of I. okamurae by both liquid chromatography with diode array detection and electrospray ionization mass spectrometry (LC-DAD-ESI/MS) and ABTS+ online HPLC systems: DPHC (39 mg) and OPA (23 mg) were successfully isolated from I. okamurae (500 mg) with optimum solvent composition (0.5:10:4:6; n-hexane/EtOAc/MeOH/water, v/v) with corresponding partition coefficients (K) of 1.62 and 2.71, respectively, by preparative CPC. Hence, CPC coupled with ABTS+ online HPLC is convenient for the efficient and simple isolation of these antioxidant compounds from I. okamurae.
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참고문헌 (32)
참고문헌 신청
Ahn MJ / 2006 / Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown alga, Ishige okamurae / Phytother Res 20:711~713
Ahn GN / 2007 / Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage / Eur Food Res Technol 226:71~79
Ahn MJ / 2011 / Diphlorethohydroxycarmalol, isolated from the brown algae Ishige okamurae, protects against radiation-induced cell damage in mice / Food Chem Toxicol 49:864~870
Amanda JS / 2005 / On-line high-performance liquid chromatography analysis of the antioxidant activity of phenolic compounds in green and black tea / Mol Nutr Food Res 49:52~60
Berthod A / 1988 / Centrifugal partition chromatography. 1. general features / J Liq Chromatogr 11:547~566
Ahn GN / 2007 / Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage / Eur Food Res Technol 226:71~79
Ahn MJ / 2011 / Diphlorethohydroxycarmalol, isolated from the brown algae Ishige okamurae, protects against radiation-induced cell damage in mice / Food Chem Toxicol 49:864~870
Amanda JS / 2005 / On-line high-performance liquid chromatography analysis of the antioxidant activity of phenolic compounds in green and black tea / Mol Nutr Food Res 49:52~60
Berthod A / 1988 / Centrifugal partition chromatography. 1. general features / J Liq Chromatogr 11:547~566
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Anti-obesity effects of diphlorethohydroxycarmalol isolated from Ishige okamurae are associated with activation of AMPK signaling pathway in 3T3-L1 adipocytes
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High-performance centrifugal partition chromatography(HPCPC) for efficient isolation of diphlorethohydroxycarmalol(DPHC) and screening of its antioxidant activity in a zebrafish model
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Analysis of components and Structural form of Ishige okamurae Yendo according to the Harvesting Area and Time
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Anti-melanogenic effect of diphlorethohydroxycarmalol isolated from Ishige okamurae via PKA/CREB and ERK-mediated MITF downregulation in B16F10 melanoma cells and zebrafish
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Development of a zebrafish model for muscle atrophy induced by dexamethasone: The protective role of Ishige okamurae
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