지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제1호
- 발행연도
- 2016.1
- 수록면
- 8 - 13 (6page)
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초록· 키워드
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Granulomatosis with polyangiitis (GPA) is an idiopathic vasculitis of medium and small arteries, characterized by necrotizing granulomatous inflammation. GPA typically affects upper and lower respiratory tract with coexisting glomerulonephritis. This disease is generally characterized by antineutrophil cytoplasm antibodies (ANCA), nevertheless, there are rare cases with negative ANCA. GPA affects people at any age, with predominance of the sixth and seventh decade of life. In 80%–95% of the patients the first symptoms of GPA are otorhinolaryngological manifestations of head and neck including nose/sinuses, ears, eyes, larynx/trachea, oral cavity, and salivary glands. Diagnosis of GPA is based on Criteria of the American College of Rheumatology. In clinical practice diagnosis, the presence of distinctive ANCA antibodies and biopsy of affected organ are crucial. GPA must be differentiated from neoplastic, infectious or inflammatory ulcerative lesions of the head and neck. The standard treatment procedure is divided into two essential phases, induction and maintenance. The induction phase is based on combination of systemic corticosteroid and immunosuppressant therapy, whereas the maintenance phase comprises corticosteroids and azathioprine/methotrexate supplementation. Surgical treatment ought to be considered for patients who are not responding to pharmacotherapy.
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참고문헌 (51)
참고문헌 신청
Watts RA. / 2001 / Epidemiology of vasculitis in Europe / Ann Rheum Dis 60(12):1156~1157
Reinhold-Keller E. / 2000 / An interdisciplinary approach to the care of patients with Wegener’s granulomatosis : long-term outcome in 155 patients / Arthritis Rheum 43(5):1021~1032
Seo P. / 2004 / The antineutrophil cytoplasmic antibody-associated vasculitides / Am J Med 117(1):39~50
Srouji IA. / 2007 / Patterns of presentation and diagnosis of patients with Wegener’s granulomatosis : ENT aspects / J Laryngol Otol 121(7):653~658
Holle JU. / 2010 / Prospective long-term follow-up of patients with localised Wegener’s granulomatosis : does it occur as persistent disease stage? / Ann Rheum Dis 69(11):1934~1939
Reinhold-Keller E. / 2000 / An interdisciplinary approach to the care of patients with Wegener’s granulomatosis : long-term outcome in 155 patients / Arthritis Rheum 43(5):1021~1032
Seo P. / 2004 / The antineutrophil cytoplasmic antibody-associated vasculitides / Am J Med 117(1):39~50
Srouji IA. / 2007 / Patterns of presentation and diagnosis of patients with Wegener’s granulomatosis : ENT aspects / J Laryngol Otol 121(7):653~658
Holle JU. / 2010 / Prospective long-term follow-up of patients with localised Wegener’s granulomatosis : does it occur as persistent disease stage? / Ann Rheum Dis 69(11):1934~1939
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