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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 34 - 41 (8page)
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Background/Aims: Transient elastography (TE) has been proposed as a promising noninvasive alternative to hepatic venous pressure gradient (HVPG) for detecting portal hypertension (PH). However, previous studies have yielded conflicting results. We gathered evidence from literature on the clinical usefulness of TE versus HVPG for assessing PH.
Methods: We conducted a systematic review by searching databases for relevant literature evaluating the clinical usefulness of non-invasive TE for assessing PH in patients with cirrhosis. A literature search in Ovid Medline, EMBASE and the Cochrane Library was performed for all studies published prior to December 30, 2015.
Results: Eight studies (1,356 patients) met our inclusion criteria. For the detection of PH (HVPG ≥6 mmHg), the summary sensitivity and specificity were 0.88 (95% confidence interval [CI] 0.86-0.90) and 0.74 (95% CI 0.67-0.81), respectively.
Regarding clinically significant PH (HVPG ≥10 mmHg), the summary sensitivity and specificity were 0.85 (95% CI 0.63-0.97) and 0.71 (95% CI 0.50-0.93), respectively. The overall correlation estimate of TE and HVPG was large (0.75, 95% CI: 0.65; 0.82, P<0.0001).
Conclusions: TE showed high accuracy and correlation for detecting the severity of PH. Therefore, TE shows promise as a reliable and non-invasive procedure for the evaluation of PH that should be integrated into clinical practice.
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참고문헌 (22)
참고문헌 신청
Baik SK / 2010 / Haemodynamic evaluation by Doppler ultrasonography in patients with portal hypertension: a review / Liver Int 30 : 1403 ~ 1413
Berzigotti A / 2013 / Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis / Gastroenterology 144 : 102 ~ 111
Bureau C / 2008 / Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease / Aliment Pharmacol Ther 27 :
Carrion JA / 2006 / Transient elastography for diagnosis of advanced fibrosis and portal hypertension in patients with hepatitis C recurrence after liver transplantation / L
Eom YW / 2015 / Mesenchymal stem cell therapy for cirrhosis:present and future perspectives / World J Gastroenterol 21 : 10253 ~ 10261
Berzigotti A / 2013 / Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis / Gastroenterology 144 : 102 ~ 111
Bureau C / 2008 / Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease / Aliment Pharmacol Ther 27 :
Carrion JA / 2006 / Transient elastography for diagnosis of advanced fibrosis and portal hypertension in patients with hepatitis C recurrence after liver transplantation / L
Eom YW / 2015 / Mesenchymal stem cell therapy for cirrhosis:present and future perspectives / World J Gastroenterol 21 : 10253 ~ 10261
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