지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 12 - 19 (8page)
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Purpose: The aim of this study was to determine the structural changes of the urinary bladder after chronic spinal cord injury (SCI) in minipigs with the primary focus on the analysis of urinary bladder wall proteins and their quantitative distribution.
Methods: Seven Göttingen minipigs (adult, female) underwent a complete spinal cord transection. Follow-up time was 4 months during which the bladder was drained by frequent single catheterisation and data from the bladder diary and daily urine strip test were collected. Samples from the urinary bladder were taken, fixed in 4% paraformaldehyde and stained for histological analyses. Bladder wall thickness, single tissue quantities/distributions, types I and III collagen, and elastin quantifications were performed. Comparisons to healthy urinary bladder tissue of age-matched minipigs were performed for statistical analyses.
Results: No urinary tract infections were observed in our SCI minipig collective during follow-up. A trend towards a reduction in bladder volumes and an increase in incontinence periods were seen. The bladder wall thickness significantly increased after chronic SCI. Furthermore, bladder wall composition was severely altered by a significant loss of smooth muscle tissue and a significant increase in connective tissue. Elastic fibres were reduced in number and altered in their structural appearance after SCI. Type I collagen was significantly increased, while type III collagen was significantly decreased after SCI.
Conclusions: Chronic SCI highlighted that the urinary bladder wall undergoes fibrotic events with reduced contractile and elastic properties due to changes of the bladder wall protein composition. These changes show in detail how SCI severely influences the urinary bladder wall composition and depicts the similarities between minipigs and humans.
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참고문헌 (20)
참고문헌 신청
Andersson KE / 2004 / Urinary bladder contraction and relaxation : physiology and pathophysiology / Physiol Rev 84 : 935 ~ 986
Bossowska A / 2009 / Distribution and neurochemical characterization of sensory dorsal root ganglia neurons supplying porcine urinary bladder / J Physiol Pharmacol 60 (Suppl
Chen G / 2012 / The inhibitory effects of pudendal nerve stimulation on bladder overactivity in spinal cord injury dogs: is early stimulation necessary? / Neuromodulation 15
Cruz CD / 2011 / Spinal cord injury and bladder dysfunction : new ideas about an old problem / Scientific World Journal 11 : 214 ~ 234
Dalmose AL / 2005 / Stereotactic electrical stimulation of the pontine micturition centre in the pig / BJU Int 95 : 886 ~ 889
Bossowska A / 2009 / Distribution and neurochemical characterization of sensory dorsal root ganglia neurons supplying porcine urinary bladder / J Physiol Pharmacol 60 (Suppl
Chen G / 2012 / The inhibitory effects of pudendal nerve stimulation on bladder overactivity in spinal cord injury dogs: is early stimulation necessary? / Neuromodulation 15
Cruz CD / 2011 / Spinal cord injury and bladder dysfunction : new ideas about an old problem / Scientific World Journal 11 : 214 ~ 234
Dalmose AL / 2005 / Stereotactic electrical stimulation of the pontine micturition centre in the pig / BJU Int 95 : 886 ~ 889
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