지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,144 - 1,151 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Pleural effusion, an accumulation of fluid in the pleural space, usually occurs in patients when the rate of fluid formation exceeds the rate of fluid removal. The differential diagnosis of tuberculous pleurisy and malignant pleural effusion is a difficult task in high tuberculous prevalence areas. The aim of the present study was to identify novel biomarkers for the diagnosis of pleural fluid using proteomics technology.
Materials and Methods: We used samples from five patients with transudative pleural effusions for internal standard, five patientswith tuberculous pleurisy, and the same numbers of patients having malignant effusions were enrolled in the study. We analyzedthe proteins in pleural fluid from patients using a technique that combined two-dimensional liquid-phase electrophoresis and matrix assisted laser desorption/ionization-time of flight-mass spectrometry.
Results: We identified a total of 10 proteins with statistical significance. Among 10 proteins, trasthyretin, haptoglobin, metastasis-associated protein 1, t-complex protein 1, and fibroblast growth factor-binding protein 1 were related with malignant pleural effusionsand human ceruloplasmin, lysozyme precursor, gelsolin, clusterin C complement lysis inhibitor, and peroxirexdoxin 3 were expressed several times or more in tuberculous pleural effusions.
Conclusion: Highly expressed proteins in malignant pleural effusion were associated with carcinogenesis and cell growth, and proteins associated with tuberculous pleural effusion played a role in the response to inflammation and fibrosis. These findings will aid in the development of novel diagnostic tools for tuberculous pleurisy and malignant pleural effusion of lung cancer.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Sauter ER / 2001 / Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium / Int J Cancer 92:374~381
Cernat RI / 2011 / Serum trace metal and ceruloplasmin variability in individuals treated for pulmonary tuberculosis / Int J Tuberc Lung Dis 15:1239~1245
Oikonomou N / 2009 / Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis / Thorax 64:467~475
Rhee SG / 2005 / Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling / Free Radic Biol Med 38:1543~1552
Alban A / 2003 / A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal sta
Cernat RI / 2011 / Serum trace metal and ceruloplasmin variability in individuals treated for pulmonary tuberculosis / Int J Tuberc Lung Dis 15:1239~1245
Oikonomou N / 2009 / Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis / Thorax 64:467~475
Rhee SG / 2005 / Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling / Free Radic Biol Med 38:1543~1552
Alban A / 2003 / A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal sta
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Therapeutic efficacy of radiolabeled antibodies in mice model of malignant pleural effusion
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Importance of the Cell Block Technique in Diagnosing Patients with Non-Small Cell Carcinoma Accompanied by Pleural Effusion
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Refractory Pleural Effusion in Systemic Lupus Erythematosus Treated by Pleurectomy
대한류마티스학회지
2017 .01
-
Elevated Pleural Adenosine Deaminase Levels in IgG4-related Disease With Pleural Effusion: A Case Series
Annals of Laboratory Medicine
2023 .01
-
Adenosine Deaminase 수치가 높은 골수종 흉수 1예
대한내과학회지
2016 .01
-
Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in the Pleural Fluid
Infection and Chemotherapy
2021 .09
-
유방암의 폐전이로 인한 흉막 삼출의 한의치료에 대한 증례보고
대한한방내과학회지
2021 .01
-
Eosinophilia in Pleural Effusions: a Speculative Negative Predictor for Malignancy
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
난치성 편측 흉수와 불응성 혈소판 감소증으로 나타난 흉강내 혈관내피종 1예
Allergy Asthma & Respiratory Diseases
2016 .01
-
결핵성 흉막염으로 오인된 악성중피종
영남의대학술지
2015 .01
-
결핵성 흉막염으로 오인된 악성중피종
Journal of Yeungnam Medical Science
2015 .06
-
Malignant Pleural Effusion from Metastatic Prostate Cancer: A Case Report with Unusual Cytologic Findings
Journal of Pathology and Translational Medicine
2018 .01
-
Disappearance of pericardial effusion by suspected pericardial-pleural fistula in a Miniature Schnauzer dog
Korean Journal of Veterinary Research(대한수의학회지)
2018 .07
-
ALK-positive anaplastic large cell lymphoma that presented as pleural effusion
Blood Research
2022 .03
-
Pleuroperitoneal communication-associated pleuritis as an uncommon cause of fever of unknown origin in a child on peritoneal dialysis: a case report
Childhood Kidney Diseases
2023 .06
-
Peritoneal lymphomatosis with pleural and peritoneal effusions in a dog: a case report
Korean Journal of Veterinary Research(대한수의학회지)
2023 .09
-
프로피오니박테륨 아크네(Propionibacterium acnes)에 의한 의인성농흉
Allergy Asthma & Respiratory Diseases
2019 .01
-
폐암 수술 후 흉막 내 미세잔류병변 판정사례
항공우주의학회지
2021 .08
-
Medical Thoracoscopy in Pleural Disease: Experience from a One-Center Study
Tuberculosis and Respiratory Diseases
2017 .01
-
A Case of Extensive IgG4-Related Disease Presenting as Massive Pleural Effusion, Mediastinal Mass, and Mesenteric Lymphadenopathy in a 16-Year-Old Male
Tuberculosis and Respiratory Diseases
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0