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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 124 - 132 (9page)
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초록· 키워드
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Adrenal hormones are essential for the timely differentiation and maturation of fetal organs and the regulation of intrauterine homeostasis. These hormones play complex roles during fetal life, and they are believed to provide the cellular communication that coordinates maternal-fetal interactions. Cortisol serves to modulate functional adaptations for extrauterine life in the perinatal period. Serum cortisol levels of preterm infants are similar to basal levels reported for healthy full-term neonates.
However, a rise of cortisol production is absent during illness. Compared with a fetus of a similar gestational age, premature maturation of the hypothalamic-pituitary- adrenal (HPA) axis is suggested in preterm infants; however, the inappropriate cortisol value observed in severe illness is due to immaturity of 11β-hydroxylase activity and an immature response of the brain to stress. Cardiovascular instability associated with adrenal insufficiency is more frequent than formerly reported, and replacing glucocorticoids in the treatment of refractory hypotension is effective without an increase in short term adverse consequences. However, the diagnostic criteria and optimal management have not yet been determined. Thus, further understanding of perinatal adrenal function will provide insight into the improved management of preterm infants.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Alkalay AL / 1996 / Evaluation of hypothalamic-pituitary-adrenal axis in premature infants treated with dexamethasone / Am J Perinatol 13 : 473 ~ 477
Benediktsson R / 1997 / Placental 11beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure / Clin Endocrinol 46 : 161 ~ 166
Bird JA / 1996 / Endocrine and metabolic adaptation following caesarean section or vaginal delivery / Arch Dis Child Fetal Neonatal Ed 74 : F132 ~ 134
Bolt RJ / 2002 / Maturity of the adrenal cortex in very preterm infants is related to gestational age / Pediatr Res 52 : 405 ~ 410
Hanna CE / 1993 / Hypothalamic pituitary adrenal function in the extremely low birth weight infant / J Clin Endocrinol Metab 76 : 384 ~ 387
Benediktsson R / 1997 / Placental 11beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure / Clin Endocrinol 46 : 161 ~ 166
Bird JA / 1996 / Endocrine and metabolic adaptation following caesarean section or vaginal delivery / Arch Dis Child Fetal Neonatal Ed 74 : F132 ~ 134
Bolt RJ / 2002 / Maturity of the adrenal cortex in very preterm infants is related to gestational age / Pediatr Res 52 : 405 ~ 410
Hanna CE / 1993 / Hypothalamic pituitary adrenal function in the extremely low birth weight infant / J Clin Endocrinol Metab 76 : 384 ~ 387
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