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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 371 - 378 (8page)
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This study was conducted to examine the efects of dietary grape extracts on preneoplastic foci for-mation in rat hepatocarcinogenesis, and related hepatic enzymes. Male Sprague-Dawley rats were fed basal diet or grape diet containing 15% con-centrated grape extracts (68 bricks). The grape diet groups were divided into whole-period grape diet group (DEN-GW; grape diet group fed throughout group (DEN-GP; grape diet group fed from post initiation stage) acording to the starting time point of the grape diet. Hepatocarcinogenesis was in-duced by diethylnitrosamine (DEN; 200 mg/kg bw) and 2/3 partial hepatectomy (DEN-B; DEN-treated basal diet group, DEN-GW, and DEN-GP groups), while the control group treated with saline and sham operation (Control group). The formation of pla-cental glutathione (GSH) S-transferase positive (GST-P+) foci in DEN-GW group was moderately GP group. Thiobarbituric acid reactive substances content of DEN-GW group was significantly lower than that of DEN-B group. The activity of faty acid synthase (FAS) in the grape diet groups was de-creased about 1/2 of the DEN-B group. The con-tent of GSH and GSH peroxidase activity were in-creased by carcinogen treatment, but not modul-ated by grape diet. The activities of GSH S-trans-ferase, p-nitrophenol hydroxylase, and catalase were not affected by diet or treatment. Conclu-sively, the grape diet-induced reduction of FAS tisues, might be one of the contributing mecha-nisms of hepatic cancer prevention.
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