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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 144 - 149 (6page)
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Prostaglandin D_2 is a major lipid mediator released from activated mast cells of which metabolite 9α,11β-prostaglandin F2 are used as a biomarker of mast cell activation in various type of asthma. Prostagladin D_2 acts on DP_1 (DP, PTGDR), CRTH2 (DP_2) and TP receptors resulting in bronchoconstriction and airway eosinophilia and increase of Th2 cytokines. Several single nucleotide polymorphisms of DP and CRTH2 has been reported to be associated with asthma susceptibility in some population. Thus, prostaglandin D_2 may play an important role for the pathogenesis of asthma. Therefore, prostaglandin D_2 could be a potential new therapeutic target for asthma. Indeed, several CRTH2 antagonists are currently under investigation for the treatment for asthma. Here, this review will summarize the biosynthesis of prostaglandin D_2 and its receptors and focus on the role of prostaglandin D_2 in the pathogenesis of asthma including genetic association studies.
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참고문헌 (24)
참고문헌 신청
Bochenek G / 2004 / Plasma 9alpha,11beta-PGF2, a PGD2 metabolite, as a sensitive marker of mast cell activation by allergen in bronchial asthma / Thorax 59 : 459 ~ 464
Boyce JA / 2008 / Eicosanoids in asthma, allergic inflammation, and host defense / Curr Mol Med 8 : 335 ~ 349
Choi JH / 2011 / PGD2 biosynthesis in several human mast cell models is catalyzed by cycloxygenase-1 / Annual meeting of European Respiratory Society
Daham K / 2011 / Effects of celecoxib on major prostaglandins in asthma / Clin Exp Allergy 41 : 36 ~ 45
Dahlen SE / 2004 / Monitoring mast cell activation by prostaglandin D2 in vivo / Thorax 59 : 453 ~ 455
Boyce JA / 2008 / Eicosanoids in asthma, allergic inflammation, and host defense / Curr Mol Med 8 : 335 ~ 349
Choi JH / 2011 / PGD2 biosynthesis in several human mast cell models is catalyzed by cycloxygenase-1 / Annual meeting of European Respiratory Society
Daham K / 2011 / Effects of celecoxib on major prostaglandins in asthma / Clin Exp Allergy 41 : 36 ~ 45
Dahlen SE / 2004 / Monitoring mast cell activation by prostaglandin D2 in vivo / Thorax 59 : 453 ~ 455
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