지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 94 - 97 (4page)
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초록· 키워드
오류제보하기
Because nail psoriasis is difficult to treat, therapy with many biological drugs has been attempted. Ustekinumab is approved for chronic plaque psoriasis and psoriatic arthritis (PsA), with some trials reporting nail improvement using this agent. A 51-year-old man with severe chronic plaque psoriasis had severe involvement of all fingernails and toenails, with accompanying nail fold psoriasis. He also had PsA of the small joints of the fingers. Despite multiple conventional therapies, the nail lesions did not improve, and his nail psoriasis severity index score was 97. After a fourth ustekinumab injection, most of the fingernail psoriasis was resolved, and only hyperkeratosis remained on both large toenails.
Because the nail plate, nail fold, and small joints of the fingers are closely apposed structures within a small area, cytokines produced from the nail units overflow to the nail fold and small joints and can induce nail fold psoriasis and PsA.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Jiaravuthisan MM. / 2007 / Psoriasis of the nail : anatomy, pathology, clinical presentation, and a review of the literature on therapy / J Am Acad Dermatol 57:1~27
Gupta AK. / 2009 / Psoriatic nail disease: quality of life and treatment / J Cutan Med Surg 13(Suppl 2):S102~S106
Reich K. / 2005 / Infliximab induction and maintenance therapy for moderate-to-severe psoriasis : a phase III, multicentre, double-blind trial / Lancet 366:1367~1374
Rich P. / 2014 / Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis : results from PHOENIX1 / Br J Dermatol 170:398~407
Thaçi D. / 2015 / Adalimumab for the treatment of moderate to severe psoriasis : subanalysis of effects on scalp and nails in the BELIEVE study / J Eur Acad Dermatol Venereol 29:353~360
Gupta AK. / 2009 / Psoriatic nail disease: quality of life and treatment / J Cutan Med Surg 13(Suppl 2):S102~S106
Reich K. / 2005 / Infliximab induction and maintenance therapy for moderate-to-severe psoriasis : a phase III, multicentre, double-blind trial / Lancet 366:1367~1374
Rich P. / 2014 / Ustekinumab improves nail disease in patients with moderate-to-severe psoriasis : results from PHOENIX1 / Br J Dermatol 170:398~407
Thaçi D. / 2015 / Adalimumab for the treatment of moderate to severe psoriasis : subanalysis of effects on scalp and nails in the BELIEVE study / J Eur Acad Dermatol Venereol 29:353~360
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