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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 385 - 390 (6page)
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Leptin, an adipokine regulating energy metabolism, appears to be associated with breast cancer progression. Insulin-like growth factor-1 (IGF-1) mediates the pathogenesis of breast cancer. The regulation of IGF-1 expression by leptin in breast cancer cells is unclear. Here, we found that leptin upregulates IGF-1 expression at the transcriptional level in breast cancer cells. Activating protein-1 (AP-1)-binding element within the proximal region of IGF-1 was necessary for leptin-induced IGF-1 promoter activation. Forced expression of AP-1 components, c-FOS or c-JUN, enhanced leptin-induced IGF-1 expression, while knockdown of c-FOS or c-JUN abrogated leptin responsiveness. All three MAPKs (ERK1/2, JNK1/2, and p38 MAPK) mediated leptin-induced IGF-1 expression. These results suggest that leptin contributes to breast cancer progression through the transcriptional upregulation of leptin via the MAPK pathway.
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참고문헌 (35)
참고문헌 신청
Zhang Y / 1994 / Positional cloning of the mouse obese gene and its human homologue / Nature 372:425~432
Huang L / 2000 / Leptin : a multifunctional hormone / Cell Res 10:81~92
Friedman JM / 1998 / Leptin and the regulation of body weight in mammals / Nature 395:763~770
Margetic S / 2002 / Leptin : a review of its peripheral actions and interactions / Int J Obes Relat Metab Disord 26:1407~1433
Hu X / 2002 / Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development / J Natl Cancer Inst 94:1704~1711
Huang L / 2000 / Leptin : a multifunctional hormone / Cell Res 10:81~92
Friedman JM / 1998 / Leptin and the regulation of body weight in mammals / Nature 395:763~770
Margetic S / 2002 / Leptin : a review of its peripheral actions and interactions / Int J Obes Relat Metab Disord 26:1407~1433
Hu X / 2002 / Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development / J Natl Cancer Inst 94:1704~1711
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