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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 520 - 525 (6page)
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Dihydroartemisinin (DHA) has been reported to possess anti-cancer activity against many cancers. However, the pharmacologic effect of DHA on HBV-positive hepatocellular carcinoma (HCC) remains unknown. Thus, the objective of the present study was to determine whether DHA could inhibit the proliferation of HepG2.2.15 cells and uncover the underlying mechanisms involved in the effect of DHA on HepG2.2.15 cells. We found that DHA effectively inhibited HepG2.2.15 HCC cell proliferation both in vivo and in vitro. DHA also reduced the migration and tumorigenicity capacity of HepG2.2.15 cells. Regarding the underlying mechanisms, results showed that DHA induced cellular senescence by up-regulating expression levels of proteins such as p-ATM, p-ATR, -H2AX, P53, and P21 involved in DNA damage response. DHA also induced autophagy (green LC3 puncta gathered together and LC3II/LC3I ratio increased through AKT-mTOR pathway suppression). Results also revealed that DHA-induced autophagy was not linked to senescence or cell death. TPP1 (telomere shelterin) overexpression could not rescue DHA-induced anticancer activity (cell proliferation). Moreover, DHA down-regulated TPP1 expression. Gene knockdown of TPP1 caused similar phenotypes and mechanisms as DHA induced phenotypes and mechanisms in HepG2.2.15 cells. These results demonstrate that DHA might inhibit HepG2.2.15 cells proliferation through inducing cellular senescence and autophagy.
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참고문헌 (26)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36cancers in 185 countries / CA Cancer J Clin 68:394~424
Mokdad AA / 2014 / Liver cirrhosis mortality in 187 countries between 1980 and 2010 : a systematic analysis / BMC Med 12:145
Eastman RT / 2009 / Artemisinin-based combination therapies : a vital tool in efforts to eliminate malaria / Nat Rev Microbiol 7:864~874
Tong Y / 2016 / Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/beta-catenin signaling / Oncotarget 7:31413~31428
Ontikatze T / 2014 / Dihydroartemisinin is a hypoxia-active anti-cancer drug in colorectal carcinoma cells / Front Oncol 4:116
Mokdad AA / 2014 / Liver cirrhosis mortality in 187 countries between 1980 and 2010 : a systematic analysis / BMC Med 12:145
Eastman RT / 2009 / Artemisinin-based combination therapies : a vital tool in efforts to eliminate malaria / Nat Rev Microbiol 7:864~874
Tong Y / 2016 / Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/beta-catenin signaling / Oncotarget 7:31413~31428
Ontikatze T / 2014 / Dihydroartemisinin is a hypoxia-active anti-cancer drug in colorectal carcinoma cells / Front Oncol 4:116
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