지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Chronic hypoxia is a major cause that increases neonatal mortality in the perinatal period. Vascular endothelial growth factor (VEGF) and its receptors induced by hypoxia are increased blood vessel permeability in the developing central nervous system and characterized as a critical factor in angiogenesis and vasculogenesis. This study investigated the development of the rat cerebellum with expression of VEGF and its receptors under chronic hypoxia in compare with normoxia. In addition, this study can contribute to the understanding of the effect development in the postnatal cerebellum. Rat pups were divided into two groups, normoxia and hypoxia group. The cerebellum of 35-day-old rat was removed and prepared for immunofluorescent staining. After staining, the sections were observed under the fluorescent microscope and were taken the picture using the microscopic-digital camera system. Expression of VEGF and Flk-1 restricted only to Purkinje cells, but feline sarcoma virus-like tyrosine kinase-1 (Flt-1) did not express in all of cerebellar layers. Under chronic hypoxia, expression of VEGF and fetal liver kinase-1 (Flk-1) increased in Purkinje cells but no changes in case of Flt-1. These results suggest that the source of VEGF and Flk-1 is Purkinje cells in the cerebellum. And increase of VEGF and Flk-1 expression in the murine cerebellum results from adaptive responses to chronic hypoxia.
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참고문헌 (26)
참고문헌 신청
Carlevaro MF / 2000 / Vascular endothelial growth factor (VEGF)in cartilage neovascularization and chondrocyte differentiation: auto- paracrine role during endochondral bone formation / J Cell Sci 113:59~69
Chow J / 2001 / Astrocyte derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro / Brain Res Dev Brain Res 130:123~132
Dong XX / 2009 / Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases / Acta Pharmacol Sin 30:379~387
Fu WL / 2011 / Proliferation and apoptosis property of mesenchymal stem cells derived from peripheral blood under the culture conditions of hypoxia and serum deprivation / Chin Med J 124:3959~3967
Gupta A / 2012 / Neuroimaging of cerebrovascular disease in the aging brain / Aging Dis 3:414~425
Chow J / 2001 / Astrocyte derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro / Brain Res Dev Brain Res 130:123~132
Dong XX / 2009 / Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases / Acta Pharmacol Sin 30:379~387
Fu WL / 2011 / Proliferation and apoptosis property of mesenchymal stem cells derived from peripheral blood under the culture conditions of hypoxia and serum deprivation / Chin Med J 124:3959~3967
Gupta A / 2012 / Neuroimaging of cerebrovascular disease in the aging brain / Aging Dis 3:414~425
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