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- 자료유형
- 학술저널
- 저자정보
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- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제20권 제1호
- 발행연도
- 2019.1
- 수록면
- 1 - 7 (7page)
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Inflammation is an important protective response mechanism that occurs against microbial invasion or injury. However, excessive inflammation may lead to cause of morbidity and mortality in diseases. The activated macrophages plays a vital role in inflammatory response by stimulation of lipopolysaccharide (LPS) and tumor necrosis factor-α (TNF-α). This activation further damages the host by inducing certain pro-inflammatory mediators such as nitric oxide (NO), interleukin-1β (IL-1β), interleukin-6 (IL-6), TNF-α, inducible nitrous oxide (iNOS) and cyclooxygenase (COX-2). Flavonoids are bioactive compounds with potential effects as anti-cancer, anti-inflammation, anti-viral and anti-bacterial activities. Polymethoxyflavones (PMFs) are unique to citrus plants which are of specific interest owing to their biological effects that includes lipoprotein metabolism and anti-inflammatory activity. Sinensetin is one of the PMFs having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C4 position. Sinensetin have been known for exerting various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, there are no studies focused on the anti-inflammatory effects of sinensetin on skeletal muscle cells. In the present study, we investigated the anti-inflammatory effect of flavonoids isolated from Sinensetin on the production of pro-inflammatory mediators mediated by nuclear factor-kappa B (NF-κB) by inhibition of signal transduction in LPS - induced L6 skeletal muscle cells.
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참고문헌 (40)
참고문헌 신청
Nair KS / 2005 / Aging muscle / Am J Clin Nutr 81:953~963
Bastard JP / 2006 / Recent advances in the relationship between obesity, inflammation, and insulin resistance / Eur Cytokine Netw 17:4~12
안나영 / 2016 / 노화와 면역 TLR4/SOCS3 신호전달기전의 운동 효과 / 한국여성체육학회지 30(2):253~269
Staples WH / 2016 / Geriatric physical therapy: a case study approach / Mc Graw Hill Education
Schrager MA / 2007 / Sarcopenic obesity and inflammation in the In CHIANTI study / J Appl Physiol 102:919~925
Bastard JP / 2006 / Recent advances in the relationship between obesity, inflammation, and insulin resistance / Eur Cytokine Netw 17:4~12
안나영 / 2016 / 노화와 면역 TLR4/SOCS3 신호전달기전의 운동 효과 / 한국여성체육학회지 30(2):253~269
Staples WH / 2016 / Geriatric physical therapy: a case study approach / Mc Graw Hill Education
Schrager MA / 2007 / Sarcopenic obesity and inflammation in the In CHIANTI study / J Appl Physiol 102:919~925
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