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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제53권 제4호
- 발행연도
- 2019.1
- 수록면
- 244 - 252 (9page)
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Background: Ovarian epithelial cancer (OEC) is the second-most common gynecologic malignancy. CD109 expression is elevated in human tumor cell lines and carcinomas. A previous study showed that CD109 expression is elevated in human tumor cell lines and CD109 plays a role in cancer progression. Therefore, this study aimed to determine whether CD109 is expressed in OEC and can be useful in predicting the prognosis. Methods: Immunohistochemical staining for CD109 and reverse transcription-quantitative polymerase chain reaction was performed. Then we compared CD109 expression and chemoresistance, overall survival, and recurrence-free survival of OEC patients. Chemoresistance was evaluated by dividing into good-response group and poor-response group by the time to recurrence after chemotherapy. Results: CD109 expression was associated with overall survival (p = .020), but not recurrence-free survival (p = .290). CD109 expression was not an independent risk factor for overall survival due to its reliability (hazard ratio, 1.58; p = .160; 95% confidence interval, 0.82 to 3.05), although we found that CD109 positivity was related to chemoresistance. The poor-response group showed higher rates of CD109 expression than the good-response group (93.8% vs 66.7%, p = .047). Also, the CD109 mRNA expression level was 2.88 times higher in the poor-response group as compared to the good-response group (p = .001). Conclusions: Examining the CD109 expression in patients with OEC may be helpful in predicting survival and chemotherapeutic effect.
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참고문헌 (31)
참고문헌 신청
Montes AF / 2012 / Ovarian cancer: basic science perspective / InTech :1~16
Flam F / 1988 / Symptomatology of ovarian cancer / Eur J Obstet Gynecol Reprod Biol 27:53~57
Goff BA / 2000 / Ovarian carcinoma diagnosis / Cancer 89:2068~2075
Liu J / 2014 / New strategies in ovarian cancer : translating the molecular complexity of ovarian cancer into treatment advances / Clin Cancer Res 20:5150~5156
Hartmann LC / 1994 / Prognostic significance of p53 immunostaining in epithelial ovarian cancer / J Clin Oncol 12:64~69
Flam F / 1988 / Symptomatology of ovarian cancer / Eur J Obstet Gynecol Reprod Biol 27:53~57
Goff BA / 2000 / Ovarian carcinoma diagnosis / Cancer 89:2068~2075
Liu J / 2014 / New strategies in ovarian cancer : translating the molecular complexity of ovarian cancer into treatment advances / Clin Cancer Res 20:5150~5156
Hartmann LC / 1994 / Prognostic significance of p53 immunostaining in epithelial ovarian cancer / J Clin Oncol 12:64~69
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